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    Glossary Ectodysplasin A2 Receptor

    regulates development of skin, hair, and ectodermal tissues

    The Ectodysplasin A2 Receptor (EDA2R) is a protein found on the surface of certain cells that plays a crucial role in the development of skin, hair, and other ectodermal tissues. Mutations in the gene encoding this receptor can lead to conditions like ectodermal dysplasia, which can result in abnormalities in hair growth, skin texture, and dental development.

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    Research 30 of 316

    1. Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness Human Genetics · 2009 · 42 citations
    2. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    3. Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark Research Square (Research Square) · 2021 · 3 citations
    4. p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss FEBS Letters · 2010 · 37 citations
    5. Genetic and molecular aspects of androgenetic alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018 · 24 citations
    6. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    7. A review of genetic researches of and rogenic alopecia Int J Genet · 2016
    8. The Roles of EDA2R in Ageing and Disease Aging Cell · 2025 · 1 citations
    9. Stimulation of ectodermal organ development by Ectodysplasin-A1 Developmental Biology · 2003 · 249 citations
    10. Feather arrays are patterned by interacting signalling and cell density waves PLoS Biology · 2019 · 133 citations
    11. Epidermal patterning and induction of different hair types during mouse embryonic development Birth defects research · 2009 · 81 citations
    12. A new mutation resulting in the truncation of the TRAF6-interacting domain of XEDAR: a possible novel cause of hypohidrotic ectodermal dysplasia: Figure 1 Journal of Medical Genetics · 2012 · 17 citations
    13. Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases International Journal of Molecular Sciences · 2022 · 6 citations
    14. Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats Scientific Reports · 2025 · 1 citations
    15. Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene Experimental Dermatology · 2010 · 26 citations
    16. Significant Correction of Disease after Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia American Journal of Human Genetics · 2007 · 109 citations
    17. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features Nature Communications · 2016 · 196 citations
    18. A Tale of Two Haplotypes: The EDA2R/AR Intergenic Region is the Most Divergent Genomic Segment between Africans and East Asians in the Human Genome Human Biology · 2012 · 4 citations
    19. Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis Clinical and Experimental Dermatology · 2011 · 41 citations
    20. Lower prostate cancer risk in Swedish men with the androgen receptor E213 A-allele Cancer Causes & Control · 2017
    21. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005 · 195 citations
    22. Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies Experimental Dermatology · 2020 · 15 citations
    23. Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies Frontiers in Pharmacology · 2026
    24. Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency Molecular and Cellular Biology · 2004 · 75 citations
    25. Genetic Variants and Lifestyle Factors in Androgenetic Alopecia Patients: A Case–Control Study of Single Nucleotide Polymorphisms and Their Contribution to Baldness Risk Nutrients · 2025
    26. Coordinating the Sculptors: Ectodysplasin-A (EDA) Signaling Cross-Talk with Skeletogenic Pathways Preprints.org · 2025
    27. Human Hair and the Impact of Cosmetic Procedures: A Review on Cleansing and Shape-Modulating Cosmetics Cosmetics · 2016 · 53 citations
    28. Edar Signaling in the Control of Hair Follicle Development 2005 · 71 citations
    29. EDA Missense Variant in a Cat with X-Linked Hypohidrotic Ectodermal Dysplasia Genes · 2024
    30. Comparing Current Therapeutic Modalities of Androgenic Alopecia: A Literature Review of Clinical Trials Cureus · 2023 · 1 citations