Female Androgenetic Alopecia

January 2015 in “ Hair transplant forum international ”

Andrew G. Messenger, Silke Redler, Regina C. Betz

female androgenetic alopecia androgenetic alopecia AGA Female Pattern Hair Loss estrogen receptor gene ESR2 antiandrogen treatments hormonal factors female AGA FPHL estrogen receptor antiandrogens

Studysummary This abstract introduces a historical perspective on Dorothy Osborn's research about the hereditary nature of common baldness but reports no new study results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

17 / 17 results

research Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

21 citations , December 2013 in “Archives of Dermatological Research”

No link found between new male baldness genes and female hair loss.

research The Estrogen Receptor 2 (ESR2) Gene in Female-Pattern Hair Loss: Replication of Association with rs10137185 in German Patients

4 citations , December 2013 in “British Journal of Dermatology”

This study reports an association between the ESR2 gene variant rs10137185 and female-pattern hair loss in German patients.

research Investigation of Six Novel Susceptibility Loci for Male Androgenetic Alopecia in Women With Female Pattern Hair Loss

25 citations , July 2013 in “Journal of Dermatological Science”

This study suggests that the androgen receptor locus on the X chromosome may play a role in the pathogenesis of early-onset female pattern hair loss.

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

74 citations , January 2013 in “Journal of Investigative Dermatology”

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

research Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

87 citations , May 2012 in “PLOS Genetics”

This study found that early-onset androgenetic alopecia in individuals of European ancestry is significantly associated with increased odds of Parkinson's disease and is influenced by specific genetic loci, including some linked to reduced fertility.

research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

38 citations , February 2012 in “British Journal of Dermatology”

This study suggests that the AR/EDA2R locus may contribute to early-onset female pattern hair loss, but no association was found with the 20p11 locus.

research Association Analysis of Estrogen Receptor Beta Gene (ESR2) Polymorphisms with Female Pattern Hair Loss

27 citations , October 2011 in “British Journal of Dermatology”

This study builds on previous findings by associating female pattern hair loss with gene polymorphisms related to oestrogen activity, suggesting oestrogen's role in the condition.

research Improvement in Scalp Hair Growth in Androgen-Deficient Women Treated with Testosterone: A Questionnaire Study

21 citations , October 2011 in “British Journal of Dermatology”

This study found that subcutaneous testosterone therapy improved scalp hair growth in a majority of androgen-deficient women who previously reported hair thinning and did not report hair loss as a side effect.

research Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome

54 citations , February 2010 in “British Journal of Dermatology”

This case report describes a patient with complete androgen insensitivity syndrome experiencing female pattern hair loss, suggesting that factors beyond direct androgen action may contribute to this condition in women.

research Why Some Women Look Young for Their Age

175 citations , November 2009 in “PLOS ONE”

This study found that both genetic and environmental factors influence appearance-related aging in women, with skin wrinkling, hair graying, and sun damage significantly affecting perceived age more than chronological age.

research Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11

140 citations , October 2008 in “Nature Genetics”

research Male-Pattern Baldness Susceptibility Locus at 20p11

111 citations , October 2008 in “Nature Genetics”

In their study, Tim Spector and colleagues identified a new genetic association at chromosome 20p11.22 with male-pattern baldness, confirmed by the increased risk when combined with a known androgen receptor gene variant.

research Genetic Basis of Male Pattern Baldness

191 citations , December 2003 in “Journal of Investigative Dermatology”

Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.

research Effects of Minoxidil 2% vs. Cyproterone Acetate Treatment on Female Androgenetic Alopecia: A Controlled, 12-Month Randomized Trial

149 citations , June 2002 in “British Journal of Dermatology”

Minoxidil works better for female hair loss, but cyproterone reduces scalp oiliness and causes menstrual issues.

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

239 citations , November 2000 in “Journal of The American Academy of Dermatology”

In this study, finasteride 1 mg/day for 12 months did not improve hair growth or slow hair thinning in postmenopausal women with androgenetic alopecia compared to placebo.

research Diffuse Female Hair Loss: Are Androgens Necessary?

110 citations , September 1999 in “British Journal of Dermatology”

This case report describes a young woman with hypopituitarism who experienced hair loss typical of female androgenetic alopecia without detectable androgens, suggesting this hair loss pattern may not always be androgen dependent.