TLDR Swedish men with the E213 A-allele of the androgen receptor have a lower risk of prostate cancer.
In a study involving 12,121 men from the Malmö Diet and Cancer Study (MDCS) and 1,120 men from the Swedish Osteoporotic fractures in men study (MrOS), researchers found that Swedish men with the androgen receptor E213 A-allele (H2 haplotype) had a 32% lower risk of being diagnosed with prostate cancer (PCa) compared to those with the H1 haplotype. The study, which included 628 men with PCa and 1,374 controls, supported previous research indicating a protective effect of the H2 haplotype against PCa in Europeans. The association was significant in the larger MDCS cohort but not in the smaller MrOS cohort. The research also considered the possibility of genotype-adjusted PSA levels but found no significant differences in tumor characteristics or mortality risk between haplotype carriers. The findings underscore the complex interplay between androgen receptor haplotypes, PCa risk, and other factors, and suggest that the biological mechanisms are influenced by a variety of factors. The study was funded by the Swedish Cancer Society and other Swedish research funds, and it benefited from the comprehensive data of the Swedish National Cancer Registry.
9 citations,
September 2014 in “Cancer Epidemiology, Biomarkers & Prevention” Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.
41 citations,
March 2012 in “Clinical and Experimental Dermatology” G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.
60 citations,
January 2007 in “Human Genetics” AR polyglycine repeat doesn't cause baldness.
195 citations,
July 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
23 citations,
January 2014 in “International Journal of Biological Sciences” African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.
9 citations,
September 2014 in “Cancer Epidemiology, Biomarkers & Prevention” Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.
76 citations,
April 2005 in “Cancer Epidemiology, Biomarkers & Prevention” E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.
13 citations,
September 2022 in “Biomolecules” The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.