Lower Prostate Cancer Risk in Swedish Men with the Androgen Receptor E213 A-Allele

February 2017 in “ Cancer Causes & Control ”

Magdalena Bentmar Holgersson, Yasir Ruhayel, Magnus K. Karlsson, Aleksander Giwercman, Anders Bjartell, Claes Ohlsson, Dan Mellström, Östen Ljunggren, Mohammad-Ali Haghsheno, Jan-Erik Damber, Yvonne Lundberg Giwercman

androgen receptor E213 A-allele H2 haplotype prostate cancer PCa genotype-adjusted PSA levels tumor characteristics mortality risk biological mechanisms PSA levels

Studysummary In this study, Swedish men carrying the AR haplotype H2 were found to have a significantly lower risk of prostate cancer compared to those with the more common H1 variant.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

In a study involving 12,121 men from the Malmö Diet and Cancer Study (MDCS) and 1,120 men from the Swedish Osteoporotic fractures in men study (MrOS), researchers found that Swedish men with the androgen receptor E213 A-allele (H2 haplotype) had a 32% lower risk of being diagnosed with prostate cancer (PCa) compared to those with the H1 haplotype. The study, which included 628 men with PCa and 1,374 controls, supported previous research indicating a protective effect of the H2 haplotype against PCa in Europeans. The association was significant in the larger MDCS cohort but not in the smaller MrOS cohort. The research also considered the possibility of genotype-adjusted PSA levels but found no significant differences in tumor characteristics or mortality risk between haplotype carriers. The findings underscore the complex interplay between androgen receptor haplotypes, PCa risk, and other factors, and suggest that the biological mechanisms are influenced by a variety of factors. The study was funded by the Swedish Cancer Society and other Swedish research funds, and it benefited from the comprehensive data of the Swedish National Cancer Registry.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Androgen Receptor Polymorphism-Dependent Variation in Prostate-Specific Antigen Concentrations of European Men

9 citations , September 2014 in “Cancer Epidemiology, Biomarkers & Prevention”

This study found that men without prostate cancer carrying the A-allele of SNP rs1204038 had a 65% higher risk of PSA levels above 3 ng/mL compared to those with the G-allele, increasing referrals for further examination.

research Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis

41 citations , October 2011 in “Clinical and Experimental Dermatology”

This meta-analysis suggests that the G allele of AR StuI polymorphism might be a potential risk factor for AGA, particularly in white populations.

Recent Positive Selection of a Human Androgen Receptor/Ectodysplasin A2 Receptor Haplotype and Its Relationship to Male Pattern Baldness

research Recent Positive Selection of a Human Androgen Receptor/Ectodysplasin A2 Receptor Haplotype and Its Relationship to Male Pattern Baldness

42 citations , April 2009 in “Human Genetics”

This study suggests that the AGA risk haplotype in Europeans was driven to high frequency by positive selection, likely associated with a variant in the EDA2R gene.

Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

60 citations , January 2007 in “Human Genetics”

In this study, researchers found that while the SNP rs6152 is strongly associated with androgenetic alopecia, the GGN triplet repeat is not, suggesting the causative variant is likely a non-coding one.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.