June 2019 in “PRISM (University of Calgary)” This research reported that dermal progenitor cells can enhance split-thickness skin graft outcomes by improving dermal layer qualities and reducing itch and offer potential in skin wound healing using a flowable hydrogel for better cell delivery and survival.
January 2006 in “Chinese Journal of Dermatology” This study found that cultured dermal papilla cells can induce hair follicle regeneration and sustain hair growth both in vivo and in vitro, with their effectiveness linked to specific protein expression levels.
8 citations
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January 2020 in “International Journal of Trichology” Silymarin improves hair follicle health better than vitamin C by boosting cell growth and reducing oxidative stress.
5 citations
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March 2011 in “Journal of proteomics” This study found that exposing dermal papilla cells to sub-lethal doses of colchicine releases histone H4, which inhibits cell growth and decreases alkaline phosphatase activity, potentially explaining colchicine-induced hair loss.
4 citations
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May 2025 in “Cells” This study found that miR-370-3p targets SMAD4 to inhibit cell proliferation, promote apoptosis, and affect the cell cycle in follicular papilla cells, demonstrating differences in their expression in sheep tissues, which may impact hair follicle development.
1 citations
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January 2007 in “Chinese Journal of Dermatology” In this in vitro study, baicalin promoted human hair follicle growth, potentially by enhancing VEGF secretion by dermal papilla cells.
November 2022 in “Scientific Data” This study identified downstream genes regulated by androgen receptor signaling in dermal papilla cells and suggests potential molecular targets for treating androgenetic alopecia and prostate cancer.
January 2022 in “Yokohama National University Repository (Yokohama National University)” This study found that exosomes from human dermal papilla cell cultures, particularly in an oxygen-permeable 3D environment, most effectively supported hair follicle stem cell maintenance and promoted hair follicle formation in vitro.
81 citations
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September 2013 in “PLoS ONE” This study identified gene expression differences between dermal papilla cells from primary and secondary hair follicles in Cashmere goats, highlighting their roles in hair follicle morphogenesis.
55 citations
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September 2003 in “Experimental Dermatology” In this study, researchers found that certain cytokines can significantly down-regulate PDGF expression in dermal papilla cells and follicular keratinocytes, indicating a potential link between PDGF signaling and catagen induction.
12 citations
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June 2022 in “International Journal of Molecular Sciences” In this study, copper was found to promote the proliferation of dermal papilla cells in Rex rabbits by maintaining the function of the cellular mitochondrial electron transport chain.
4 citations
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March 2008 in “Korean Journal of Chemical Engineering” Mesenchymal cells can significantly boost human hair growth and longevity.
4 citations
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June 2007 in “PubMed” This study found that using engineered skin with PGA-collagen scaffolds, combined with hair follicle stem cells and other cell types, effectively repaired full-thickness skin defects in nude mice.
1 citations
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July 2025 in “Journal of Photochemistry and Photobiology B Biology” Photobiomodulation helps protect hair follicle cells from damage caused by DHT.
April 2026 in “Biomedical and Biotechnology Research Journal (BBRJ)” In this study, researchers observed that using microtube-based forced aggregation, human hair follicle dermal papilla cells formed stable, compact spheroids at higher cell densities, showing enhanced expression of specific markers compared to 2D culture.
February 2026 in “International Journal of Molecular Sciences” In this study, the researchers found that cholinergic signaling via M4 muscarinic receptors influences hair growth, with enhanced elongation observed upon activation with bethanechol, highlighting its potential role in hair biology using mouse models.
November 2025 in “Biomolecules” This study found that overexpressing FGF22 in dermal papilla cells enhanced hair follicle stem cell proliferation and viability, while its knockout reduced these attributes, indicating its role in hair follicle regeneration.
December 2024 in “Regenerative Therapy” This study found that altering levels of SFRP1 in human dermal papilla cells affects cell function and regulates Wnt/β-catenin signaling or telomerase activity, suggesting that targeting SFRP1 could potentially offer a new approach to treat hair loss diseases.
November 2024 in “Genomics” This study found that exogenous melatonin enhances the development of secondary hair follicles in Cashmere goats by promoting miRNA-mRNA interactions, specifically via the chi-let-7d-5p/WNT2 axis, which suggests a mechanism for melatonin's effects on hair growth involving microRNA regulation.
July 2024 in “International Journal of Molecular Sciences” In this study, Nigella sativa oil was found to promote dermal papilla cell proliferation and may reduce oxidative stress, suggesting its potential as a hair loss intervention.
This study found that DNA methylation may regulate the differential expression of the BMP7 gene in Hu sheep lamb skin of different patterns, and it influences the proliferation and cell cycle of dermal papilla cells, with demethylation treatment increasing BMP7 expression and cell proliferation.
May 2023 in “Research Square (Research Square)” This study found that botulinum toxin type A may reduce apoptosis in dermal papillary cells induced by dihydrotestosterone through the circ_0135062/miR-506-3p/Bax axis.
January 2014 in “프로그램북(구 초록집)” This study suggests that certain electrical settings may enhance hair growth by stimulating dermal papilla cell proliferation and increasing gene expression related to hair growth in vitro and in rabbit skin.
46 citations
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October 2023 in “Science Advances” In this study, researchers used 3D bioprinting to successfully create engineered skin tissues with hair follicle-like structures, potentially enhancing skin grafts and safety testing for chemical compounds by more closely mimicking natural skin complexity.
32 citations
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February 2002 in “Veterinary Dermatology” This study reported that canine dermal papilla cells showed a distinct growth pattern and strong collagen IV and laminin staining compared to dermal fibroblasts.
28 citations
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May 2019 in “Life Sciences” This study found that ginsenoside Rb1 promoted the growth of mink hair follicles and dermal papilla cells, potentially through activating the PI3K/AKT/GSK-3β signaling pathway.
15 citations
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March 2022 in “Acta Biomaterialia” This study demonstrated that a 3D bioprinting technique using a gelatin/alginate hydrogel scaffold can regenerate entire hair follicles in mice, offering potential advancements in hair loss treatment.
13 citations
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August 2020 in “Frontiers in Cell and Developmental Biology” This study found that Twist1 and Tcf4 synergistically regulate the hair follicle induction ability of dermal papilla cells by forming a complex with β-catenin, enhancing their biological properties.
11 citations
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August 2021 in “Aging” This study found that TGF-β2 may enhance collagen expression and spheroid formation in human dermal papilla cells, which could improve their hair inductivity and maintenance.
9 citations
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July 2020 in “Cell Proliferation” In this study, EREG promoted hair growth by activating specific receptors in cell and animal models, indicating it may be a potential treatment for hair loss.