A Multimodal Approach to Augmenting Wound Healing: Progress Toward Dermal Regeneration in Mammals

    June 2021 in “ PRISM (University of Calgary) ”
    Holly D. Sparks
    TLDR DPCs and new biomaterials can greatly improve skin healing.
    The document discussed the potential of dermal progenitor cells (DPCs) in enhancing wound healing and promoting dermal regeneration in mammals. It was found that DPCs, which originate from the hair follicle mesenchyme, could be transplanted to improve the outcomes of split-thickness skin grafts by repopulating the dermal layer, enhancing viscoelastic properties, and reducing itch. The study also explored the use of a synthetic hydrogel platform to improve DPC delivery and survival, showing promise for tailored wound healing applications. Additionally, the research highlighted the regenerative capabilities of reindeer antler velvet as a model for understanding tissue regeneration. Overall, the findings underscored the therapeutic potential of DPCs and innovative biomaterials in advancing skin regeneration and reducing scarring.
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