17 citations
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December 2019 in “Stem Cell Research & Therapy” Grouping certain skin cells together activates a growth pathway that helps create new hair follicles.
18 citations
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November 2013 in “Molecules and Cells” New culture method keeps human skin stem cells more stem-like.
12 citations
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September 2020 in “Stem cell research & therapy” Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.
April 2021 in “Journal of Investigative Dermatology” The study demonstrated that early-stage bilayer tissue-engineered skin substitutes (TESSs), created using adult scalp dermal progenitor cells and epidermal stem cells with type I collagen, showed improved skin structure and wound healing in vivo. These TESSs were grafted onto full-thickness wounds in mice and evaluated after 4 and 8 weeks. Early-stage TESSs resulted in a normal stratified epidermis, higher proliferation marker levels, and thicker dermis with more vimentin- and CD31-positive cells. Notably, hair follicle formation was observed only in early-stage TESSs. These findings suggested that early-stage TESSs could potentially enhance clinical wound healing due to their efficient grafting and reduced apoptotic pathway activation.
June 2021 in “PRISM (University of Calgary)” DPCs and new biomaterials can greatly improve skin healing.