A Novel Cell-Free Regenerative Therapy for Hair Loss: Human Fetal Cartilage Progenitor Cell Secretome

August 2025 in “ Biomaterials ”

Ngoc-Trinh Tran, Minh‐Dung Truong, Hee‐Woong Yun, Byoung‐Hyun Min

human fetal cartilage progenitor cell secretome extracellular matrix proteins bioactive factors dermal papilla cells hair follicle regeneration β-catenin signaling epithelial-mesenchymal interactions hair follicle germ formation minoxidil ShFCPC DP cells

TLDR A new therapy using secretions from fetal cartilage cells shows promise for safe and effective hair regrowth.

The study introduces a novel cell-free regenerative therapy for hair loss using the secretome of human fetal cartilage progenitor cells (ShFCPC). ShFCPC is rich in extracellular matrix proteins and bioactive factors that enhance dermal papilla (DP) cell function, crucial for hair follicle regeneration. The therapy activates β-catenin signaling, improves epithelial-mesenchymal interactions, and promotes hair follicle germ formation. In vivo tests on nude mice and rats showed significant hair regrowth and improved follicle structure, outperforming minoxidil. ShFCPC demonstrated a 94.9% hair coverage compared to 44.7% in controls, with no observed toxicity, indicating its potential as a safe and effective treatment for hair loss.

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