FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation

    November 2025 in “ Biomolecules ”
    Yu Luo, Tong Xiao, Binpeng Xi … Tingting Guo
    Studysummary This study found that overexpressing FGF22 in dermal papilla cells enhanced hair follicle stem cell proliferation and viability, while its knockout reduced these attributes, indicating its role in hair follicle regeneration.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 19

    1. Identification of lncRNAs Involved in the Hair Follicle Cycle Transition of Cashmere Goats in Response to Photoperiod Change BMC Genomics · 2025
    2. FGF20 Secreted From Dermal Papilla Cells Regulates the Proliferation and Differentiation of Hair Follicle Stem Cells in Fine-Wool Sheep Journal of Animal Physiology and Animal Nutrition · 2024
    3. Shh Gene Regulates Proliferation and Apoptosis of Dermal Papilla Cells in Secondary Hair Follicle Growth Cycle of Cashmere Goats Animals · 2024
    4. Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep Genes · 2023
    5. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    6. SIRT7 Activates Quiescent Hair Follicle Stem Cells to Ensure Hair Growth in Mice EMBO journal · 2020
    7. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    8. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    9. Regulating Hair Follicle Stem Cells Immunity · 2017
    10. Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling Journal of Investigative Dermatology · 2015
    11. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    12. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    13. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    14. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    15. A Review: The Location, Molecular Characterization and Multipotency of Hair Follicle Epidermal Stem Cells Annals of the Academy of Medicine Singapore · 2004
    16. Hair Follicle Stem Cells: Insights from the 2003 Workshop ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    17. Primary Cell Culture and Morphological Characterization of Canine Dermal Papilla Cells and Dermal Fibroblasts Veterinary Dermatology · 2002
    18. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    19. Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000