FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation

    November 2025 in “ Biomolecules ”
    Yu Luo, Tong Xiao, Binpeng Xi, Yufang Song, Zengkui Lu, Chao Yuan, Jianbin Liu, Tingting Guo
    This study investigates the role of FGF22 secreted by dermal papilla cells (DPCs) in regulating hair follicle stem cell (HFSC) proliferation and differentiation. Using a DPC-HFSC co-culture system, it was found that FGF22 overexpression in DPCs significantly increased FGFR1/FGFR2 mRNA expression and HFSC viability while reducing apoptosis. Conversely, FGF22 knockout decreased FGFR1/FGFR2 expression, reduced HFSC proliferation, and increased apoptosis. FGF22 promotes HFSC proliferation and differentiation by activating Wnt/β-Catenin, Sonic Hedgehog, and Notch signaling pathways, while inhibiting BMP pathways. These findings provide insights into potential applications in regenerative medicine and hair loss treatment.
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