Primary Observation on Construction of Skin with Human Hair Follicle Bulge Cells Using Tissue Engineering Technique

The study investigated the use of human hair follicle bulge cells (HFBCs) and dermal papilla cells (DPCs) in tissue-engineered skin to repair full-thickness skin wounds in nude mice. The engineered skin, using PGA-collagen scaffolds, was divided into two groups: one with both HFBCs and DPCs, and a control with only DPCs. Results showed that both groups effectively repaired skin defects, but the group with HFBCs and DPCs developed more complex skin structures, including hair-follicle-like structures by 6 weeks post-operation. The study concluded that HFBCs could enhance the repair of skin structure and function, indicating their potential role in wound healing.