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    Glossary DNA Methyltransferase 1

    maintains DNA methylation patterns during cell division

    DNA Methyltransferase 1 (DNMT1) is an enzyme that plays a crucial role in maintaining DNA methylation patterns during cell division. It adds methyl groups to the cytosine bases of DNA, which can regulate gene expression by turning genes on or off. This process is essential for normal development, genomic stability, and cellular differentiation.

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    1. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 72 citations
    2. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 1 citations
    3. 1336 The de novo DNA methyltransferase DNMT3A is required for epidermal homeostasis Journal of Investigative Dermatology · 2018
    4. Epigenetic Modulation of ESR1 and DNMT3A Following Finasteride Exposure: Implications for Female Reproductive Function Physiology · 2026
    5. OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases Stem Cell Research & Therapy · 2019 · 57 citations
    6. DNA Methylation as an Epigenetic Memory Keeper during Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018 · 1 citations
    7. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    8. Hypothalamic DNA methylation in rats with dihydrotestosterone‐induced polycystic ovary syndrome: effects of low‐frequency electro‐acupuncture Experimental physiology · 2018 · 18 citations
    9. Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice Journal of Tissue Engineering and Regenerative Medicine · 2022 · 6 citations
    10. Acetate meliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation Research Square (Research Square) · 2022 · 1 citations
    11. DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo BioMed Research International · 2019 · 20 citations
    12. 766 H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes 2023
    13. The effect of DNMTs and MBPs on hypomethylation in systemic lupus erythematosus Journal of Dermatological Science · 2008 · 6 citations
    14. Tratamiento de la Depresión durante el embarazo: perspectivas clínicas Anales (Reial Acadèmia de Medicina de la Comunitat Valenciana) · 2012
    15. Author response: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ 2017
    16. Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis Journal of Dermatological Science · 2004 · 47 citations
    17. Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling BMC genomics · 2018 · 28 citations
    18. Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat Cells · 2020 · 24 citations
    19. Epigenetic regulation in adult stem cells and cancers Cell & Bioscience · 2013 · 20 citations
    20. Tailored chromatin modulation to promote tissue regeneration Seminars in Cell & Developmental Biology · 2019 · 10 citations
    21. Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma European Journal of Clinical Pharmacology · 2016 · 26 citations
    22. DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging Clinical Cosmetic and Investigational Dermatology · 2025
    23. Reshaped DNA methylation cooperating with homoeolog‐divergent expression promotes improved root traits in synthesized tetraploid wheat New phytologist · 2024
    24. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease Genes & Development · 2008 · 667 citations
    25. Standard DNA Methylation Analysis in Mouse Epidermis: Bisulfite Sequencing, Methylation-Specific PCR, and 5-Methyl-Cytosine (5mC) Immunological Detection Methods in molecular biology · 2013 · 7 citations
    26. Melatonin in Dermatology Indian Dermatology Online Journal · 2025
    27. Integrated Analysis of Methylome and Transcriptome Changes Reveals the Underlying Regulatory Signatures Driving Curly Wool Transformation in Chinese Zhongwei Goats Frontiers in Genetics · 2020 · 39 citations
    28. Second International Symposium—Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases 2017 · 2 citations
    29. Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation‐Related Enzyme, and Molecular Docking Studies BioMed Research International · 2025
    30. Dynamic changes of genomic methylation profiles at different growth stages in Chinese Tan sheep 2021 · 35 citations