The Editor's Choice: Summary of Studies on Skin and Hair Conditions

In the document from July 2018, several studies on skin and hair conditions were summarized. Kim MK et al. found that UV radiation increases DNMT1 expression and decreases TIMP2 expression in human skin, suggesting UV-induced DNMT1 mediates DNA hypermethylation in TIMP2. Darlenski R et al. reported that 311 nm narrowband UVB phototherapy improves psoriasis symptoms and oxidative stress parameters. Hattori M et al. discovered a novel KIT mutation in mild piebaldism that affects protein function and intracellular localization. Lee M et al. demonstrated that both resident and monocyte-derived Langerhans cells contribute to psoriasis-like dermatitis, with monocyte-derived cells having a greater capacity for IL-23 production. Choi HI et al. showed that cilostazol, a PDE3 inhibitor, promotes human hair growth by enhancing proliferation and growth factor secretion in dermal papilla cells and stimulating anagen induction. Lastly, Hsu CY found that microtubule stabilization with paclitaxel or epothilone B can repair barrier defects in reconstructed human epidermis, suggesting a potential treatment for skin disorders with barrier dysfunction.