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This study found that targeting androgen receptors with prostate cancer drugs ARN509 and finasteride induced remission and increased survival in a leukemia mouse model, suggesting a potential new treatment approach for acute myeloid leukemia.

This study identified downstream genes regulated by androgen receptor signaling in dermal papilla cells and suggests potential molecular targets for treating androgenetic alopecia and prostate cancer.

This study found that intracrine androgen signaling, mediated by steroid 5α-reductase, is essential for optimal decidualization and vascular development in the endometrium during pregnancy, indicating potential targets for improving age-related fertility issues.

This study suggests that a specific region upstream of the TGF-β1 gene may play a key role in androgenetic alopecia by regulating gene expression in a cell-specific manner.

This review highlights that natural DHT blockers like saw palmetto and pumpkin seed oil show promise in managing androgenetic alopecia, though clinical data varies, and further research is needed to confirm their efficacy and safety in comparison to conventional pharmaceuticals.

In this study, DHT inhibited hair regrowth and promoted hair follicle miniaturization in mice, with skin-resident myeloid cells enhancing their interaction with hair follicular cells, especially in females.

This article reviews the impact of diet on acne, suggesting that dairy and high-glycemic foods may contribute to acne development, but it presents no new clinical findings.

In this study, ozenoxacin was found to inhibit sebum production in insulin- and 5α-DHT-differentiated hamster sebocytes in a dose-dependent manner, suggesting potential benefits in acne management by combining antimicrobial activity against C. acnes with reduced sebum production.

The authors concluded that while finasteride 1 mg affects prostate-related pathways, evidence is insufficient to prove clinical benefits for prostate outcomes compared to the established effectiveness of finasteride 5 mg.

This review article reports that oxidative stress is a key mechanism in the development of androgenetic alopecia, interacting with genetic and hormonal factors to damage hair follicle cells and potentially informing future treatment strategies.

In this review, extensive analysis using conditional mutant mice revealed that androgen and Wnt signals play crucial roles in the development and function of male external genitalia and erectile tissue, while also exploring various regulatory factors involved in their pathogenesis.

This study found that vascular endothelial growth factor may protect hair follicle stem cells from androgen-induced apoptosis in androgenic alopecia patients via the PI3K/Akt pathway.

This study isolated a bioactive peptide from Trapa japonica fruit and found that it may protect human dermal papilla cells from DHT-induced stress, suggesting potential for biomedical applications.

This article discusses the hypothesis that mechanisms driving androgenic alopecia may reduce the risk and proliferation of prostate cancer by increasing prostaglandin D2 levels but presents no new clinical findings.

This study found that in male yaks, 5α-red1 may play a crucial role in synthesizing DHT to promote hair follicle growth, while E2 synthesized by epithelial cells may inhibit this growth through ERα.

Genes controlling hair growth and immune response are disrupted in male pattern baldness.

This review investigates molecular mechanisms behind PCOS pathogenesis and discusses potential therapies, but reports no new clinical results.

This study found that in vitro treatments with 5alpha-reductase inhibitors and androgen receptor antagonists strongly stimulate VEGF expression in dermal papilla cells.

This study found that Undariopsis peterseniana extract may promote hair growth by activating specific cellular pathways, suggesting potential for treating alopecia.

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

In this study, quercitrin was reported to promote hair growth and cell viability in cultured human dermal papilla cells by enhancing cellular energy metabolism and growth factor production via MAPK/CREB signaling.

This study found that a titrated extract of Centella asiatica enhanced the hair growth potential of 3D spheroid cultured human dermal papilla cells.

In this study, researchers found no significant differences in serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology linked to the condition.

This literature review discusses the challenges and potential strategies for creating fully functional hair follicles capable of active cycling, emphasizing the molecular mechanisms, signaling pathways, and innovative regenerative techniques, such as hair micropatterning and three-dimensional printing, crucial for optimizing hair follicle regeneration.

This source reviews mechanisms and existing treatments for hair aging, highlighting factors like oxidative stress and DNA repair defects that affect hair follicle and stem cell function, and discusses research limitations and future directions in the field.

This study found that low molecular weight collagen peptide from fish may promote hair growth in both human cells and mice by activating the Wnt/β-catenin signaling pathway.

The researchers reported that DHT may reduce the inflammatory responses induced by C. acnes in androgen-sensitive human sebocyte cells, suggesting a potential link between androgens and infection in sebaceous disorders.

In this study, researchers found no significant differences in the serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology is associated with this condition.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

This study found that minor ginseng saponin F2 may promote hair growth more effectively than finasteride by enhancing anagen induction and modulating the Wnt signaling pathway in cell and mouse models.