Ozenoxacin Suppresses Sebum Production by Inhibiting mTORC1 Activation in Differentiated Hamster Sebocytes

    August 2024 in “ The Journal of Dermatology ”
    Takamichi Kitano, Toshikazu Koiwai, Koki Fujikawa … Takashi Sato
    Studysummary In this study, ozenoxacin was found to inhibit sebum production in insulin- and 5α-DHT-differentiated hamster sebocytes in a dose-dependent manner, suggesting potential benefits in acne management by combining antimicrobial activity against C. acnes with reduced sebum production.
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    Research cited in this study 4

    1. Ozenoxacin Suppresses Sebum Production by Inhibiting mTORC1 Activation in Differentiated Hamster Sebocytes The Journal of Dermatology · 2024
    2. Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet British Journal of Dermatology · 2016
    3. Mechanistic Target of Rapamycin (mTOR) Expression Is Increased in Acne Patients' Skin Experimental Dermatology · 2015
    4. Linking Diet to Acne Metabolomics, Inflammation, and Comedogenesis: An Update Clinical, Cosmetic and Investigational Dermatology · 2015