The Serum Evaluation of Sex Hormones Including DHEAs, DHT, Testosterone in Oral Lichen Planus Patients

April 2025

Fahimeh Rezazadeh, Fatemeh Lavaee, Saba Dezhkameh, Aylar Afshari

DHT DHEAs testosterone androgens oral lichen planus neuroendocrine etiology dihydrotestosterone dehydroepiandrosterone sulfate

TLDR Oral lichen planus is not linked to sex hormone levels.

This study investigated the serum levels of DHT, DHEAs, and testosterone in 40 female patients with oral lichen planus (OLP) compared to 40 healthy controls. The results showed no significant differences in the levels of these androgens between the OLP patients and the control group, nor between menopausal and non-menopausal women. The findings suggest no correlation between OLP and these sex hormones, indicating that a neuroendocrine etiology for OLP is unlikely.

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Research cited in this study

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research Is Dihydrotestosterone a Classic Hormone?

4 citations , June 2017 in “Endocrine Reviews”

Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.

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The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

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