Is Dihydrotestosterone a Classic Hormone?

    June 2017 in “ Endocrine Reviews ”
    Bradley D. Anawalt
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    TLDR Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.
    The 2017 article "Is Dihydrotestosterone a Classic Hormone?" examined the role of dihydrotestosterone (DHT) in human physiology. The authors found that DHT, traditionally seen as a major sex steroid hormone in men, primarily acts as a paracrine hormone, affecting nearby cells rather than circulating throughout the body. The study revealed that the prostate and skin self-regulate DHT concentrations independently of serum DHT concentrations. It was also noted that exogenous testosterone therapy for male hypogonadism or androgen-based male hormonal contraceptives is unlikely to significantly change the prostate hormonal environment or the potential risk of prostate cancer. The article also stated that DHT does not seem to play a primary role in the development of male or female androgenic alopecia or acne. The authors concluded that further research is needed to understand DHT's physiological effects, including its specific role in cardiovascular health, sexual function, and bone health.
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