Innate Immunity Activation of Sebocyte Cells by Living Bacteria: Evidence of a Potential Immunosuppressive Effect of DHT

    April 2019 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    François‐Xavier Bernard, Vincent Lerat, Julien Garnier, C. Barrault, Nicolas Lévèque, Charles Bodet
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    TLDR DHT may reduce inflammation caused by certain bacteria in skin cells.
    The study investigated the effects of living bacteria on the innate immune response in androgen-sensitive human sebocyte cells (SEBO662AR). It was found that bacteria such as Staphylococcus aureus, Staphylococcus epidermidis, Cutibacterium acnes, and Pseudomonas aeruginosa induced the expression of chemokines, cytokines, and antimicrobial peptides. Notably, P. aeruginosa dramatically induced these genes, while C. acnes and S. aureus also caused a significant inflammatory response. Dihydrotestosterone (DHT) was shown to specifically antagonize the overexpression of chemokines induced by C. acnes, suggesting a potential immunosuppressive effect of DHT. Additionally, C. acnes enhanced the DHT-induced accumulation of lipid droplets in sebocytes, indicating a possible cooperation between bacterial infection and androgens in sebaceous disorders.
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