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    Glossary Hair Follicle Bioengineering

    scientific method to create or regenerate hair follicles

    Hair Follicle Bioengineering is a scientific field focused on creating new hair follicles or regenerating existing ones using a combination of cells, biomaterials, and growth factors. This approach aims to treat hair loss conditions like alopecia by cultivating hair follicles in a lab and then implanting them into the scalp, potentially offering a more effective and long-lasting solution compared to traditional hair restoration methods.

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    1. Defining Hair Follicles in the Age of Stem Cell Bioengineering Journal of Investigative Dermatology · 2007 · 49 citations
    2. Bioengineering the Hair Follicle Organogenesis · 2007 · 26 citations
    3. Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering Journal of Dermatological Science · 2013 · 57 citations
    4. Bioengineering of Hair Follicle-like Structure for Validation of Hair Growth Promoting Compounds Bioengineering · 2022
    5. Synergistic effects of mesenchymal stem cell secretome and Wnt10b on hair follicle regeneration in a 3D bioengineering model: a preclinical study Stem Cell Research & Therapy · 2025
    6. Pathogenesis and regenerative therapy in vitiligo and alopecia areata: focus on hair follicle Frontiers in Medicine · 2025
    7. GMP-Compliant Culture of Human Hair Follicle Cells for Encapsulation and Transplantation Cell Transplantation · 2011 · 10 citations
    8. The promising prospect of human hair follicle regeneration in the shadow of new tissue engineering strategies Tissue & Cell · 2024
    9. Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review Life · 2022 · 4 citations
    10. Strategies to utilize iPS cells for hair follicle regeneration and the treatment of hair loss disorders Elsevier eBooks · 2021
    11. TSA restores hair follicle-inductive capacity of skin-derived precursors Scientific Reports · 2019 · 18 citations
    12. Hair follicle organoids: advances in construction, applications, and translational challenges Frontiers in Cell and Developmental Biology · 2026
    13. Emerging biomedical engineering strategies for hair follicle regeneration Bioactive Materials · 2025
    14. Faculty Opinions recommendation of Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    15. Human Induced Pluripotent Stem Cell–Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo 2013 · 64 citations
    16. Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells Scientific Reports · 2017 · 42 citations
    17. Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures Frontiers in cell and developmental biology · 2021 · 10 citations
    18. Bioengineering skin using mechanisms of regeneration and repair Biomaterials · 2007 · 202 citations
    19. Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model Science Advances · 2016 · 77 citations
    20. Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease Cell Transplantation · 2016 · 1 citations
    21. Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls Bioengineering & translational medicine · 2021 · 8 citations
    22. Hair Follicle Regeneration by Transplantation of a Bioengineered Hair Follicle Germ Methods in molecular biology · 2016 · 6 citations
    23. Functional hair follicle regeneration: an updated review Signal Transduction and Targeted Therapy · 2021 · 42 citations
    24. Use of human induced pluripotent stem cell-derived CD271+CD90+ mesenchymal stem cells for the generation of hair inductive dermal cells Journal of dermatological science · 2016
    25. Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal? Stem Cells Translational Medicine · 2019 · 29 citations
    26. iPSC-based approach for human hair follicle regeneration Frontiers in Cell and Developmental Biology · 2023
    27. Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach Journal of Investigative Dermatology · 2013 · 28 citations
    28. Modelling Human Hair Follicles—Lessons from Animal Models and Beyond Biology · 2024 · 5 citations
    29. In vitro mesenchymal–epithelial interaction facilitates de novo hair follicle formation Journal of dermatological science · 2016
    30. Hair Follicle Regeneration in Skin Grafts: Current Concepts and Future Perspectives Tissue Engineering Part B-reviews · 2011 · 39 citations