Improved Fetal Hair Follicle Development by Maternal Supplement of Selenium at Nano Size (Nano-Se)

    September 2011 in “ Livestock science ”
    Xiaoying Wu, Jiguang Yao, Zhiming Yang, Wenbin Yue, Youshe Ren, Chunxiang Zhang, Xiaoni Liu, Huisheng Wang, Xingang Zhao, Shuai Yuan, Qian Wang, Liguang Shi, Lei Shi
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    Studysummary This study found that maternal Nano-Se supplementation in cashmere goats improved antioxidant status and promoted secondary hair follicle development in fetuses at 110 days.
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    The study investigated the effects of maternal dietary selenium (Nano-Se) on antioxidant status and hair follicle development in 110-day fetal skin from cashmere goats. Eighty goats were divided into two groups: one fed a basal diet and the other supplemented with 0.5 mg/kg Nano-Se. Results showed that the S group had significantly higher expression and activity of GSH-Px, IGF-1, and IGF-1R, and lower MDA levels. Additionally, IGF-1, Se, and T-AOC concentrations in fetal serum and skin, as well as fetal liver and kidney weights, were significantly increased in the S group. Although the number of primary hair follicles was similar between groups, the S group had significantly more secondary hair follicles and a higher secondary to primary follicle ratio. This indicated that Nano-Se supplementation promoted secondary follicle development, suggesting that maternal Nano-Se could enhance fetal hair follicle development and overall growth in cashmere goats.
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