Use of Urinary Bladder Matrix, a Bioactive, Acellular Scaffold, in Transplant Donor Scars and Androgenetic Alopecia: Initial Clinical Experience

February 2012 in “ The American Journal of Cosmetic Surgery ”

Gary S. Hitzig

urinary bladder matrix UBM androgenetic alopecia hair regrowth folliculogenesis

TLDR UBM helps hair regrowth in men and women with hair loss.

The document reports on a series of case studies that used urinary bladder matrix (UBM) to facilitate hair regrowth in both donor scar areas and in areas of hair loss in both men and women. The results suggest that UBM technology is a useful tool in restoration therapy in men and women with androgenetic hair loss. The study found that UBM stimulated more follicles to grow than merely the one that was transplanted, suggesting that UBM may facilitate hair regrowth in androgenetic hair loss. Although more studies are necessary to further understand the role of UBM in folliculogenesis, the initial results are promising.

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Research cited in this study

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Extracellular Matrix Degradation Products and Low-Oxygen Conditions Enhance the Regenerative Potential of Perivascular Stem Cells

research Extracellular Matrix Degradation Products and Low-Oxygen Conditions Enhance the Regenerative Potential of Perivascular Stem Cells

91 citations, July 2010 in “Tissue Engineering Part A”

Low-oxygen conditions and ECM degradation products increase the healing abilities of perivascular stem cells.

research Bioengineering the Hair Follicle

26 citations, January 2007 in “Organogenesis”

Bioengineering can potentially treat hair loss by regenerating hair follicles and cloning hair, but the process is complex and needs more research.

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations, October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

205 citations, April 2005 in “Journal of Investigative Dermatology”

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

research Androgenetic Alopecia: An Autosomal Dominant Disorder

80 citations, January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations, September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

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