Aging of Hair Follicle Stem Cells and Their Niches

    November 2022 in “ Journal of Biochemistry and Molecular Biology ”
    Hansaem Jang, Yemin Jo, Jung Hyun Lee, Sekyu Choi
    Studysummary This review discusses how aging affects hair follicle stem cells and their environment, contributing to hair loss, and explores strategies to promote hair regrowth, but reports no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 41

    1. Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Frontiers in Cell and Developmental Biology · 2021
    2. Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis Cell Stem Cell · 2021
    3. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
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    5. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020
    6. SIRT7 Activates Quiescent Hair Follicle Stem Cells to Ensure Hair Growth in Mice EMBO journal · 2020
    7. Comparison of Mitochondrial Transplantation Using a Stamp-Type Multineedle Injector and Platelet-Rich Plasma Therapy for Hair Aging in Naturally Aging Mice Biomedicine & Pharmacotherapy · 2020
    8. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    9. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    10. Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo The EMBO Journal · 2019
    11. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    12. A Novel and Safe Small Molecule Enhances Hair Follicle Regeneration by Facilitating Metabolic Reprogramming Experimental and Molecular Medicine · 2018
    13. Wnt/β-Catenin Signaling Promotes Aging-Associated Hair Graying in Mice Oncotarget · 2017
    14. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017
    15. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches Annual Review of Cell and Developmental Biology · 2016
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    17. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    18. Aging, Alopecia, and Stem Cells Science · 2016
    19. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    20. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    21. The Modulatable Stem Cell Niche: Tissue Interactions During Hair and Feather Follicle Regeneration Journal of Molecular Biology · 2015
    22. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    23. Modulating the Stem Cell Niche for Tissue Regeneration Nature Biotechnology · 2014
    24. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014
    25. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    26. The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation BioMed Research International · 2014
    27. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    28. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    29. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    30. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    31. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    32. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    33. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    34. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    35. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    36. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    37. Pharmacologic Interventions in Aging Hair Clinical Interventions in Aging · 2006
    38. Stem Cells and Their Niches Science · 2006
    39. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    40. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    41. Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles Differentiation · 1994

    Related research 4

    1. Regulation and Dysregulation of Hair Regeneration: Aiming for Clinical Application Cell Regeneration · 2022
    2. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017
    3. Skin and Hair: Models for Exploring Organ Regeneration Human Molecular Genetics · 2008
    4. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001