Role of Vitamin D in Skin and Hair Biology

    November 2023 in “ Elsevier eBooks ”
    Daniel D. Bikle, Marie B. Demay
    Studysummary This study found that vitamin D receptor mutations lead to hair follicle alopecia due to impaired cyclic regeneration, which is distinct from vitamin D receptor effects on epidermal keratinocytes that largely depend on 1,25-dihydroxyvitamin D.
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    Research cited in this study 44

    1. The Significance of CYP11A1 Expression in Skin Physiology and Pathology Molecular and Cellular Endocrinology · 2021
    2. Calcium Regulation of Stem Cells EMBO reports · 2020
    3. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    4. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    5. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization Endocrinology · 2017
    6. Absence of Vitamin D Receptor-Mediated PPARγ Suppression Causes Alopecia in VDR-Null Mice The FASEB Journal · 2016
    7. Vitamin D And Calcium Regulation Of Epidermal Wound Healing The Journal of Steroid Biochemistry and Molecular Biology · 2015
    8. Novel Mechanisms for the Vitamin D Receptor in the Skin and in Skin Cancer The Journal of Steroid Biochemistry and Molecular Biology · 2014
    9. The Vitamin D Receptor Is Required for Activation of CWnt and Hedgehog Signaling in Keratinocytes Molecular Endocrinology · 2014
    10. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014
    11. Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-Beta Signaling During the Inflammatory Response to Cutaneous Injury Endocrinology · 2012
    12. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    13. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    14. Overexpression of Hedgehog Signaling Is Associated With Epidermal Tumor Formation in Vitamin D Receptor-Null Mice Journal of Investigative Dermatology · 2011
    15. Vitamin D Metabolism and Function in the Skin Molecular and cellular endocrinology · 2011
    16. Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor Journal of Biological Chemistry · 2011
    17. Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice Journal of Cellular Physiology · 2010
    18. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    19. Quantification of the Vitamin D Receptor-Coregulator Interaction Biochemistry · 2009
    20. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    21. The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    22. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    23. Role of β-Catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer Cold Spring Harbor Symposia on Quantitative Biology · 2008
    24. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    25. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    26. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005
    27. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    28. 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    29. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    30. Overexpression of the Calcium Sensing Receptor Accelerates Epidermal Differentiation and Permeability Barrier Formation In Vivo Mechanisms of Development · 2003
    31. Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D Molecular Endocrinology · 2002
    32. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    33. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001
    34. The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor Genes & Development · 2001
    35. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    36. Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice Journal of Clinical Investigation · 2001
    37. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice Endocrinology · 2000
    38. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    39. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    40. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    41. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    42. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice Endocrinology · 1998
    43. Alopecia Universalis Associated With a Mutation in the Human Hairless Gene Science · 1998
    44. Topographical and Developmental Studies on Target Sites of 1,25 (OH)₂ Vitamin D₃ in Skin Cell & tissue research/Cell and tissue research · 1984

    Related research 4

    1. Dysfunction of Hair Follicle Mesenchymal Progenitors Is Associated with Age-Related Hair Loss ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    2. Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle Trends in pharmacological sciences · 2013
    3. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    4. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001