Thyroid Receptor β: A Promising Target for Developing Novel Anti-Androgenetic Alopecia Drugs

    May 2024 in “ Drug discovery today
    Junge Zhi, Feifan Li, Xiaoying Jiang, Renren Bai
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    TLDR Thyroid receptor β can help develop new drugs to treat hair loss.
    The paper discusses androgenetic alopecia (AGA), its prevalence, and current treatments like minoxidil and finasteride, which have limitations and side effects. It highlights thyroid receptor β (TRβ) as a promising new target for AGA treatment. TRβ agonists can directly modulate the hair cycle and promote healthy hair growth through various pathways, potentially avoiding the side effects of current treatments. The review provides an overview of existing TRβ agonists, their mechanisms, and structure-activity relationships, suggesting a new direction for developing effective anti-AGA drugs.
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