Thyroid Receptor Agonists for the Treatment of Androgenetic Alopecia

    October 2009 in “ Bioorganic & Medicinal Chemistry Letters ”
    Jie Li, Lorna Helen Mitchell, Robert J Dow
    Studysummary This study found that a thyroid hormone receptor ẞ subtype-selective thyromimetic was effective in promoting hair growth in mouse and monkey models when applied topically.
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    Research cited in this study 5

    1. Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone Journal of Investigative Dermatology · 2008
    2. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008
    3. Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice The Journal of Dermatology · 2005
    4. Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle British journal of dermatology/British journal of dermatology, Supplement · 2000
    5. Action of Topical Minoxidil in the Bald Stump-Tailed Macaque Journal of The American Academy of Dermatology · 1987