Thyroid Receptor Agonists for the Treatment of Androgenetic Alopecia

January 2010 in “ Bioorganic & Medicinal Chemistry Letters ”

Jie Li, Lorna Helen Mitchell, Robert J Dow

thyroid receptor agonists androgenetic alopecia thyromimetic PF-00277343 topical application oral thyroid hormones cardiotoxicity male pattern baldness hair growth

TLDR Thyroid receptor agonists may treat male pattern baldness without harmful side effects.

The article discusses the potential use of thyroid receptor agonists for the treatment of male pattern baldness. A novel thyromimetic, PF-00277343, has been discovered and found to be effective in stimulating hair growth in mice and monkeys after topical application, without causing systemic side effects. The use of oral thyroid hormones is impractical due to their cardiotoxicity.

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