Thyroid Receptor Agonists for the Treatment of Androgenetic Alopecia

October 2009 in “ Bioorganic & Medicinal Chemistry Letters ”

Jie Li, Lorna Helen Mitchell, Robert J Dow

thyroid receptor agonists androgenetic alopecia thyromimetic PF-00277343 topical application oral thyroid hormones cardiotoxicity male pattern baldness hair growth

Studysummary This study found that a thyroid hormone receptor ẞ subtype-selective thyromimetic was effective in promoting hair growth in mouse and monkey models when applied topically.

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The article discusses the potential use of thyroid receptor agonists for the treatment of male pattern baldness. A novel thyromimetic, PF-00277343, has been discovered and found to be effective in stimulating hair growth in mice and monkeys after topical application, without causing systemic side effects. The use of oral thyroid hormones is impractical due to their cardiotoxicity.

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Thyroid Receptor Agonists for the Treatment of Androgenetic Alopecia

Research cited in this study

research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice

research Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle

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