Thyroid Receptor Agonists for the Treatment of Androgenetic Alopecia

January 2010 in “ Bioorganic & Medicinal Chemistry Letters ”

Jie Li, Lorna Helen Mitchell, Robert J Dow

thyroid receptor agonists androgenetic alopecia thyromimetic PF-00277343 topical application oral thyroid hormones cardiotoxicity male pattern baldness hair growth

TLDR Thyroid receptor agonists may treat male pattern baldness without harmful side effects.

The article discusses the potential use of thyroid receptor agonists for the treatment of male pattern baldness. A novel thyromimetic, PF-00277343, has been discovered and found to be effective in stimulating hair growth in mice and monkeys after topical application, without causing systemic side effects. The use of oral thyroid hormones is impractical due to their cardiotoxicity.

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

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community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

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community Please stop looking for a natural way to stop your hairloss

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