Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors

September 2014 in “ PloS one ”

Constanza Contreras‐Jurado, Laura García-Serrano, Mónica Martínez‐Fernández, Lidia Ruíz-Llorente, Jesús M. Paramio, Ana Aranda

thyroid hormone receptors TRα1 TRβ keratinocyte proliferation hair follicles anagen phase alopecia re-epithelialization thyroid hormones hair growth skin repair

TLDR Thyroid hormone receptors are essential for hair growth and wound healing.

The study demonstrated that mice lacking thyroid hormone receptors (TRα1 and TRβ) exhibited impaired hair growth and delayed wound healing. These mice showed reduced keratinocyte proliferation in hair follicles, fewer anagen phases, and developed alopecia after repeated depilation. Additionally, they experienced slower re-epithelialization and reduced keratinocyte proliferation during wound healing. The findings indicated that thyroid hormones, through their receptors, played a crucial role in hair growth and skin repair, suggesting potential therapeutic targets for skin-related conditions.

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Research cited in this study

15 / 15 results

research Thyroid Hormone and Wound Healing

28 citations, January 2013 in “Journal of Thyroid Research”

Thyroid hormone may speed up wound healing and hair growth, but more research is needed to understand its role in skin repair and use as a treatment.

research Vitamin D and the Skin: Physiology and Pathophysiology

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Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

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research Exploring the Thyroid-Skin Connection: Concepts, Questions, and Clinical Relevance

49 citations, December 2009 in “Journal of Investigative Dermatology”

Thyroid function affects skin health, with a complex interaction between the two.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations, February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Alopecia: Association with Resistance to Thyroid Hormones

8 citations, January 2009 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”

A specific thyroid hormone resistance mutation may be linked to different types of hair loss.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations, August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion

253 citations, April 2008 in “Current opinion in cell biology”

Notch signalling helps skin cells differentiate and prevents tumors.

research The Hair Cycle

375 citations, February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Expression of Hypothalamic-Pituitary-Thyroid Axis Related Genes in Human Skin

155 citations, December 2002 in “Journal of Investigative Dermatology”

Thyroid-related genes are active in skin cells and may affect autoimmune conditions.

research Physiological and Retinoid-Induced Proliferations of Epidermis Basal Keratinocytes Are Differently Controlled

127 citations, July 2002 in “EMBO journal”

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations, February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations, August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle

111 citations, April 2000 in “British journal of dermatology/British journal of dermatology, Supplement”

Thyroid hormone receptor β1 is found in human hair follicles and helps them survive.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations, January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

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