Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors

September 2014 in “ PloS one ”

Constanza Contreras‐Jurado, Laura García-Serrano, Mónica Martínez‐Fernández, Lidia Ruíz-Llorente, Jesús M. Paramio, Ana Aranda

thyroid hormone receptors TRα1 TRβ keratinocyte proliferation hair follicles anagen phase alopecia re-epithelialization thyroid hormones hair growth skin repair

TLDR Thyroid hormone receptors are essential for hair growth and wound healing.

The study demonstrated that mice lacking thyroid hormone receptors (TRα1 and TRβ) exhibited impaired hair growth and delayed wound healing. These mice showed reduced keratinocyte proliferation in hair follicles, fewer anagen phases, and developed alopecia after repeated depilation. Additionally, they experienced slower re-epithelialization and reduced keratinocyte proliferation during wound healing. The findings indicated that thyroid hormones, through their receptors, played a crucial role in hair growth and skin repair, suggesting potential therapeutic targets for skin-related conditions.

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