The Basic Science of Hair Biology

    September 2012 in “ Dermatologic Clinics
    Trisia Breitkopf, Gph Leung, Man Yu, Eddy Wang, Kevin J. McElwee
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    TLDR Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.
    The document from 2013 provides an in-depth look at hair biology and the factors contributing to hair disorders, particularly focusing on alopecia. It explains that hair follicle density and size are crucial for hair coverage, with disorders like androgenetic alopecia (AGA) involving the miniaturization of hair follicles. The hair growth cycle, with its anagen, catagen, and telogen phases, is central to understanding hair disorders, as alterations in these phases can lead to conditions like AGA, telogen effluvium (TE), and alopecia areata (AA). The paper also discusses the role of genetics, hormones, and environmental factors in hair loss, noting that while androgens like dihydrotestosterone (DHT) can influence hair growth, genetic predispositions are also significant. Treatments aim to normalize hair follicle characteristics and include medications such as finasteride and minoxidil. Overall, the document concludes that hair disorders result from a complex interplay of biological components, with different factors being relevant to different conditions.
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