Advances In Polymeric Nano-Delivery Systems Targeting Hair Follicles For The Treatment Of Acne

The document explores the potential of polymeric nano-delivery systems targeting hair follicles for acne treatment, emphasizing their ability to bypass the skin's cuticle barrier. It reviews various polymer carriers, including polymer nanoparticles, micelles, nano-gels, and dendritic polymers, each offering unique drug delivery benefits. The study highlights the superior permeability of cationic polymers, despite their higher toxicity risks, and suggests strategies like embedding cationic nanocapsules in nanogels to mitigate these risks. It also discusses enhancing drug delivery through technologies like iontophoresis and microneedles. The paper underscores the need for further research to optimize these systems and explores future therapies such as acne immunotherapy and phage therapy. Additionally, it notes the potential of these systems for treating other follicle-derived conditions like alopecia.