Iontophoretic Transdermal Delivery Using Chitosan-Coated PLGA Nanoparticles for Positively Charged Drugs
October 2017
in “
Colloids and surfaces. B, Biointerfaces
”
Studysummary In this study, researchers found that chitosan-coated PLGA nanoparticles improved the iontophoretic transdermal delivery of the positively charged hydrophilic drug donepezil hydrochloride in an ex vivo rat skin model, achieving 2.2 times higher skin accumulation compared to non-coated nanoparticles.
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The study prepared Donepezil hydrochloride (DP)-loaded PLGA nanoparticles coated with chitosan (CS) to achieve a positive surface charge, enhancing their suitability for iontophoretic transdermal delivery. The CS-coated nanoparticles had an average diameter of 117.7 ± 60.6 nm and showed a 2.2-fold increase in DP skin accumulation compared to non-coated nanoparticles when iontophoresis was applied. This indicated that the chitosan coating improved the nanoparticles' ability to penetrate the skin and deliver positively charged hydrophilic drugs effectively, reaching deep hair follicles and the stratum corneum.
