Particulate Matter Exposure Induces Maternal Scalp Hair Loss After Birth in C57/B6 Mouse via Alteration of Inflammatory and Apoptotic Pathways
May 2026
in “
Frontiers in Endocrinology
”
PM2.5 postpartum hair loss inflammatory pathways apoptotic pathways IL-6 IL-1β TNF-α p-NF-κB Caspase-3 BAX/Bcl-2 ratio stratum corneum hair follicle HaCaT cells fibroblasts progesterone receptors hair follicle stem cells particulate matter inflammation apoptosis interleukin-6 interleukin-1 beta tumor necrosis factor alpha nuclear factor kappa-light-chain-enhancer of activated B cells programmed cell death skin cells connective tissue cells hormone receptors stem cells
Studysummary In a mouse model, this study found that exposure to PM2.5 leads to significant postpartum hair loss, apparent via morphological changes and elevated markers of inflammation, apoptosis, and fibrosis, potentially exacerbated by changes in hormone receptors and stem cell populations.
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