Klhl24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia

    January 2022 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Jun Cui, Qian Zhao, Zhen Song … Yang Yong
    Studysummary In this study, researchers found that the KLHL24-ΔN28 protein variant disrupts hair follicle stem cells in a mouse model, leading to premature hair loss by degrading keratin 15.
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    Research cited in this study 3

    1. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    2. The Hair Cycle Journal of Cell Science · 2006
    3. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003

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