Post-Finasteride Syndrome And The Impact Of 5-Alpha Reductase Inhibitors On Neuroendocrine And Metabolic Axes

    May 2026 in “ RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218 ”
    Antonio Oliveira de Moraes Filho, Charles Fabian de Lima, José Henrique Fulador de Oliveira … Alexandre Maslinkiewicz
    Studysummary This study reviewed recent scientific evidence on the neuroendocrine and metabolic impacts of chronic use of 5-alpha reductase inhibitors, detailing its association with sexual dysfunction, mood disorders, insulin resistance, and other metabolic disorders, suggesting persistent biopsycho-social risks beyond transient side effects in users.
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    Research cited in this study 27

    1. 5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes NeuroSci · 2026
    2. Suicidality Risks Associated with Finasteride, a 5-Alpha Reductase Inhibitor: An Evaluation of Real-World Data from the FDA Adverse Event Reports Pharmaceuticals · 2025
    3. Multidimensional Assessment of Adverse Events of Finasteride: A Real-World Pharmacovigilance Analysis Based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024 PLoS ONE · 2025
    4. Finasteride Use: Evaluation of Depression and Suicide Risk Journal of Cosmetic Dermatology · 2025
    5. Association of 5α-Reductase Inhibitors With Depression and Suicide: A Mini Systematic Review and Meta-Analysis European urology focus · 2024
    6. Sexual Dysfunction With 5-Alpha-Reductase Inhibitor Therapy for Androgenetic Alopecia: A Global Propensity Score Matched Retrospective Cohort Study Journal of the American Academy of Dermatology · 2024
    7. Analysis of Finasteride Treatment and Its Withdrawal in Rat Hypothalamus and Hippocampus at Whole-Transcriptome Level Journal of Endocrinological Investigation · 2024
    8. Factors Associated With Early-Onset Androgenetic Alopecia: A Scoping Review PLOS ONE · 2024
    9. The Post-Finasteride Syndrome: Possible Etiological Mechanisms and Symptoms International journal of impotence research · 2023
    10. Neurosteroid Influence on Affective Tone Neuroscience & Biobehavioral Reviews · 2023
    11. 5-Alpha Reductase Inhibitors Use in Prostatic Disease and Beyond Translational Andrology and Urology · 2023
    12. The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation Biomedicines · 2022
    13. Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats Biomolecules · 2022
    14. How Routine Pharmacovigilance Failed to Identify Finasteride’s Persistent Sexual Side Effects International Journal of Andrology · 2021
    15. The Connection of 5-Alpha Reductase Inhibitors to the Development of Depression Biomedicine & Pharmacotherapy · 2021
    16. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    17. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    18. Alterations of Gut Microbiota Composition in Post-Finasteride Patients: A Pilot Study Journal of Endocrinological Investigation · 2020
    19. Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia Anais Brasileiros De Dermatologia · 2020
    20. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    21. Post-Finasteride Syndrome: An Emerging Clinical Problem Neurobiology of Stress · 2019
    22. Protective Effects of Finasteride Against Testosterone-Induced Calcium Oxalate Crystallization and Crystal-Cell Adhesion Journal of Biological Inorganic Chemistry · 2019
    23. Incidence of Type 2 Diabetes Mellitus in Men Receiving Steroid 5α-Reductase Inhibitors: Population-Based Cohort Study BMJ. British medical journal · 2019
    24. Long-Term (10-Year) Efficacy of Finasteride in 523 Japanese Men with Androgenetic Alopecia Clinical research and trials · 2019
    25. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    26. Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review Dermatology Online Journal · 2017
    27. Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia Annals of Dermatology · 2016