Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats

    October 2022 in “ Biomolecules ”
    Silvia Diviccaro, Silvia Giatti, Lucia Cioffi … Roberto Cosimo Melcangi
    Studysummary This study found that in male rats, chronic finasteride treatment reduced allopregnanolone levels, which, upon drug withdrawal, correlated with increased pro-inflammatory cytokines and altered neurotransmitter levels.
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    Research cited in this study 11

    1. Allopregnanolone: An overview on its synthesis and effects Journal of Neuroendocrinology · 2021
    2. Alterations of Gut Microbiota Composition in Post-Finasteride Patients: A Pilot Study Journal of Endocrinological Investigation · 2020
    3. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    4. Post-Finasteride Syndrome: An Emerging Clinical Problem Neurobiology of Stress · 2019
    5. Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
    6. Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Sides of the Same Coin? Endocrine · 2018
    7. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
    8. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015
    9. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    10. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    11. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998

    Related research 6

    1. Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats The International Journal of Neuropsychopharmacology · 2013
    2. Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol Alcoholism: Clinical and Experimental Research · 2011
    3. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    4. Chronic Progesterone Treatment Augments While Dehydroepiandrosterone Sulphate Prevents Tolerance to Ethanol Anxiolysis and Withdrawal Anxiety in Rats European Journal of Pharmacology · 2007
    5. Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice Neuroscience · 2007
    6. The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride Pharmacology, Biochemistry and Behavior · 2006