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This study reviewed recent scientific evidence on the neuroendocrine and metabolic impacts of chronic use of 5-alpha reductase inhibitors, detailing its association with sexual dysfunction, mood disorders, insulin resistance, and other metabolic disorders, suggesting persistent biopsycho-social risks beyond transient side effects in users.

In this study, germ-free male mice showed altered levels of certain neuroactive steroids in the brain and periphery, suggesting microbiota may influence neuroendocrine pathways that support brain functioning.

This theoretical review analyzes how stress affects hair loss through hormonal and neural pathways, indicating that knowledgeable hairdressers could help in early detection and guide clients toward medical interventions, highlighting a potential collaboration between aesthetic care and medical treatment for stress-induced alopecia.

This review found significant psychosocial impacts of alopecia, noting that those with alopecia, particularly alopecia areata, experience higher rates of depression and anxiety. The review also highlighted new treatments like Janus kinase inhibitors that improve both hair regrowth and quality of life.

This review reports that alopecia, particularly alopecia areata, significantly impacts mental health and quality of life through stress and immune mechanisms, with treatments like Janus kinase inhibitors showing promise for improving both hair regrowth and psychological well-being.