Extracellular Vesicles in Skin: Biological Function and Therapeutic Potential

    September 2025 in “ International Journal of Nanomedicine ”
    Siqi Yuan, Mengyu Jin, Yanyan Zhang … Juan Wang
    Studysummary This review discusses the roles of extracellular vesicles in skin health and disease and reports no clinical results; the authors highlight potential therapeutic uses and call for more research.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 27

    1. Extracellular Vesicle as Therapeutic Agents in Anti-Aging: Mechanistic Insights and Future Potential Journal of Controlled Release · 2025
    2. Erythrocyte Extracellular Vesicles Integrate into Hair and Skin to Maintain Homeostasis Journal of Extracellular Vesicles · 2025
    3. Endocrine Controls of Skin Aging Endocrine Reviews · 2025
    4. Extracellular Vesicles as Human Therapeutics: A Scoping Review of the Literature Journal of Extracellular Vesicles · 2024
    5. Development of Pluripotent Stem Cell-Derived Epidermal Organoids That Generate Effective Extracellular Vesicles in Skin Regeneration Biomaterials · 2024
    6. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    7. Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 International Journal of Molecular Sciences · 2023
    8. Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis Burns and trauma · 2023
    9. Extracellular Vesicles From IFN-γ-Primed Mesenchymal Stem Cells Repress Atopic Dermatitis In Mice Journal of Nanobiotechnology · 2022
    10. Application of Extracellular Vesicles From Mesenchymal Stem Cells Promotes Hair Growth by Regulating Human Dermal Cells and Follicles World journal of stem cells · 2022
    11. Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics Frontiers in cell and developmental biology · 2022
    12. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    13. The Novel Mechanisms and Applications of Exosomes in Dermatology and Cutaneous Medical Aesthetics Pharmacological research · 2021
    14. MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020
    15. The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside Frontiers in immunology · 2020
    16. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    17. Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells · 2020
    18. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    19. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    20. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    21. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    22. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    23. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    24. The Diagnosis and Treatment of Hair and Scalp Diseases Deutsches Arzteblatt International · 2016
    25. Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing British Journal of Dermatology · 2015
    26. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    27. Scratching the Surface of Skin Development Nature · 2007