Mimicking Senescence Factors to Characterize the Mechanisms Responsible for Hair Regression and Hair Loss: An In Vitro Study

    July 2025 in “ Organoids
    Giacomo Masi, Cristiana Guiducci, Francesca Rescigno
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    TLDR TGF-β1 and FGF-18 are key in hair loss, and Minoxidil helps hair growth.
    This in vitro study developed dermal papilla (DP) and vascularized DP (VASC-DP) models to investigate hair regression and loss mechanisms by mimicking senescence factors. The research identified TGF-β1 and FGF-18 as key regulators of hair cycle transitions, with TGF-β1 promoting the shift from anagen to catagen and FGF-18 advancing the cycle to a telogen-like phase. The study highlighted the role of vascularization in enhancing tissue physiology and modulating gene expression, with treatments like Minoxidil promoting hair growth by activating β-catenin signaling, while Doxorubicin induced hair follicle dystrophy. The findings suggest these models are valuable for exploring hair cycle dynamics and developing personalized therapies for hair loss.
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