Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration

May 2015

Julien M. D. Legrand

STAT5 Sox18 mesenchymal-epidermal interactions hair follicle cycling hair follicle regeneration anagen entry dermal papilla macrophages collagen transcription SKPs STAT5B hair growth cycle hair regeneration skin stem cells wound healing

Studysummary This study found that STAT5 activation and Sox18 are key in regulating hair follicle induction and cycling, while transducing SKPs with active STAT5B improved wound healing by reducing inflammation.

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This study explored the roles of STAT5 and Sox18 in hair follicle cycling and regeneration, highlighting their importance in mesenchymal-epidermal interactions. STAT5 was found to enhance hair follicle dermal papilla (DP) formation and regulate hair cycling, with its activation acting as a mesenchymal switch to improve hair inductive potential. Sox18 was necessary for DP formation and function across all hair types, with its loss impairing hair development and cycling. Additionally, macrophages were shown to control collagen transcription during early wound healing, and SKPs transduced with constitutively-active STAT5B improved wound healing by reducing inflammation. These findings underscored the significance of STAT5 and Sox18 in hair follicle biology and potential therapeutic applications in wound healing.

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