Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

June 2023 in “ Frontiers in Medicine ”

Adaikalasamy Premanand, Baskaran Reena Rajkumari

androgenetic alopecia Src family protein tyrosine kinases differentially expressed genes DEGs skin epidermis hair follicle development hair cycle immune response hub genes immune processes inflammatory processes keratinization Src tyrosine kinase family genes androgen-DHT Wnt/β-catenin signaling inflammatory response AGA DHT

Studysummary This study identified core genes and pathways involved in androgenetic alopecia, finding that genes related to hair follicle development are down-regulated, while those linked to immune responses are up-regulated, highlighting potential therapeutic targets.

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