Hydrogel Microneedles Loaded With a Reactive Oxygen Species-Responsive Carbon Monoxide Donor and Finasteride for Synergistic Treatment of Androgenetic Alopecia
September 2026
in “
Advanced Materials Technologies
”
hydrogel microneedles reactive oxygen species carbon monoxide donor finasteride androgenetic alopecia CORM-401 dihydrotestosterone Wnt/β-catenin pathway TGF-β/BMP pathway testosterone-induced AGA hair follicle microenvironment local drug delivery biocompatibility systemic toxicity Propecia DHT AGA C-F-HMN patch minoxidil Rogaine
Studysummary In a mouse model study, researchers developed a methacrylated hyaluronic acid-based hydrogel microneedle patch co-loaded with finasteride and a carbon monoxide-releasing molecule for androgenetic alopecia, which showed better hair regrowth and safety compared to traditional treatments, offering an innovative approach with minimized systemic side effects.
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