Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern?

    September 2016 in “ Actas Dermo-Sifiliográficas ”
    Salvador Arias-Santiago, Francisco Camacho-Martínez
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    TLDR 5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.
    This article discusses the potential adverse effects of 5-alpha reductase inhibitor therapy in men with androgenetic alopecia. The paper cites several studies that have found sexual side effects, including erectile dysfunction and decreased libido, as well as breast complications and increased risk of male breast cancer. Other potential side effects include metabolic changes, insulin resistance, and increased risk of osteoporosis. The paper concludes that while 5-alpha reductase inhibitors can be effective in treating androgenetic alopecia, patients and physicians should be aware of the potential risks and monitor for adverse effects.
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