Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern?

    September 2016 in “ Actas Dermo-Sifiliográficas ”
    Salvador Arias-Santiago, Francisco Camacho-Martínez
    Studysummary 5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.
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    Research cited in this study 21

    1. Psychosocial Impairment as a Possible Cause of Sexual Dysfunction Among Young Men With Mild Androgenetic Alopecia: A Cross-Sectional Crowdsourcing Web-Based Study PubMed · 2016
    2. Guidelines on the Use of Finasteride in Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2016
    3. Oral Finasteride Presents With Sexual-Unrelated Withdrawal in Long-Term Treated Androgenic Alopecia in Men PubMed · 2015
    4. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    5. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    6. 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents Diabetes · 2014
    7. A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia Clinical endocrinology · 2014
    8. Long-Term Use of 5α-Reductase Inhibitors and the Risk of Male Breast Cancer Cancer Causes & Control · 2014
    9. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    10. Male Breast Cancer and 5α-Reductase Inhibitors Finasteride and Dutasteride The Journal of Urology · 2013
    11. Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2013
    12. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    13. Incomplete Recovery of Erectile Function in Rats After Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy The Journal of Sexual Medicine · 2012
    14. Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease Journal of Clinical Psychopharmacology · 2012
    15. Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia Journal of The American Academy of Dermatology · 2011
    16. Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
    17. Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study Journal of The American Academy of Dermatology · 2010
    18. Changes of Metabolic Profile in Men Treated for Androgenetic Alopecia with 1 mg Finasteride Endocrine Regulations · 2010
    19. Value of Hormonal Levels in Patients with Male Androgenetic Alopecia Treated with Finasteride: Better Response in Patients Under 26 Years Old British Journal of Dermatology · 2008
    20. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    21. Unilateral Gynecomastia Induced by Treatment with 1 mg of Oral Finasteride Archives of Dermatology · 2002

    Related research 8

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    2. What Do We Know About 5-Alpha Reductase Inhibitors? Surgical and Cosmetic Dermatology · 2018
    3. Atypical Post-Finasteride Syndrome: A Pharmacological Riddle Indian Journal of Pharmacology · 2016
    4. Current Pharmacological Treatment for Male LUTS Due to BPH: Dutasteride or Finasteride? Current Drug Targets · 2015
    5. Long-Term Use of 5α-Reductase Inhibitors and the Risk of Male Breast Cancer Cancer Causes & Control · 2014
    6. Hormonal Manipulation of Benign Prostatic Hyperplasia Current opinion in urology · 2012
    7. Finasteride for Prostatic Disease: An Updated and Comprehensive Review Expert opinion on drug metabolism & toxicology · 2008
    8. Selections from Current Literature: Androgenetic Alopecia - The Science Behind a New Oral Treatment Family Practice · 1998