Finasteride for Prostatic Disease: An Updated and Comprehensive Review

November 2008 in “ Expert opinion on drug metabolism & toxicology ”

Cosimo De Nunzio, Roberto Miano, Alberto Trucchi, Enrico Finazzi Agrò, Andrea Tubaro

finasteride steroid 5-alpha-reductase androgen benign prostatic hyperplasia Prostate Cancer Prevention Trial Propecia

TLDR Finasteride helps treat prostate issues and may prevent prostate cancer in high-risk men.

The review discussed the use of finasteride, a potent inhibitor of steroid 5-alpha-reductase, in treating prostatic disorders by lowering androgen levels in the prostate. Clinical trials showed that finasteride improved symptoms and urinary flow in men with benign prostatic hyperplasia. The Prostate Cancer Prevention Trial indicated finasteride's potential in preventing prostate cancer, though its use should be targeted at men with a higher risk of significant disease. Finasteride was recommended to be taken orally at a 5 mg daily dose.

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Research cited in this study

5 / 5 results

A Randomized Placebo-Controlled Multicenter Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis)

research A Randomized Placebo-Controlled Multicenter Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis)

127 citations, May 2004 in “PubMed”

Finasteride may help some male chronic pelvic pain patients, but more research needed.

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations, December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

research 5 Alpha-Reductase Inhibitors: What's New?

47 citations, January 2003 in “Current opinion in urology”

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.

The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

1054 citations, February 1998 in “The New England Journal of Medicine”

Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations, October 1992 in “The New England Journal of Medicine”

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

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research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations, December 2011 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

research Finasteride

187 citations, January 1994 in “The New England Journal of Medicine”

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations, October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively reduces hair loss by decreasing androgen levels.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

45 citations, August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

research The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats

14 citations, March 2018 in “Translational Stroke Research”

Finasteride helps protect brain in old male rats.

research Role of 5α-Reductase in Health and Disease

101 citations, April 1994 in “Baillière's clinical endocrinology and metabolism”

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Finasteride for Prostatic Disease: An Updated and Comprehensive Review

Research cited in this study

research A Randomized Placebo-Controlled Multicenter Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis)

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

research 5 Alpha-Reductase Inhibitors: What's New?

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

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