Finasteride for Prostatic Disease: An Updated and Comprehensive Review

November 2008 in “ Expert opinion on drug metabolism & toxicology ”

Cosimo De Nunzio, Roberto Miano, Alberto Trucchi, Enrico Finazzi Agrò, Andrea Tubaro

finasteride steroid 5-alpha-reductase androgen benign prostatic hyperplasia Prostate Cancer Prevention Trial Propecia

TLDR Finasteride helps treat prostate issues and may prevent prostate cancer in high-risk men.

The review discussed the use of finasteride, a potent inhibitor of steroid 5-alpha-reductase, in treating prostatic disorders by lowering androgen levels in the prostate. Clinical trials showed that finasteride improved symptoms and urinary flow in men with benign prostatic hyperplasia. The Prostate Cancer Prevention Trial indicated finasteride's potential in preventing prostate cancer, though its use should be targeted at men with a higher risk of significant disease. Finasteride was recommended to be taken orally at a 5 mg daily dose.

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Research cited in this study

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A Randomized Placebo-Controlled Multicenter Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis)

research A Randomized Placebo-Controlled Multicenter Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis)

127 citations, May 2004 in “PubMed”

Finasteride may help some male chronic pelvic pain patients, but more research needed.

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations, December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

research 5 Alpha-Reductase Inhibitors: What's New?

47 citations, January 2003 in “Current opinion in urology”

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.

The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

1054 citations, February 1998 in “The New England Journal of Medicine”

Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations, October 1992 in “The New England Journal of Medicine”

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

Finasteride for Prostatic Disease: An Updated and Comprehensive Review

Research cited in this study

research A Randomized Placebo-Controlled Multicenter Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis)

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

research 5 Alpha-Reductase Inhibitors: What's New?

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

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