Proteomics Reveals the Role of PLIN2 in Regulating the Secondary Hair Follicle Cycle in Cashmere Goats

    March 2025 in “ International Journal of Molecular Sciences ”
    Cuiling Wu, Qiumin Lu, Shengchao Ma … Xuefeng Fu
    Studysummary This study analyzed proteomic changes in Jiangnan cashmere goats' secondary hair follicles and found that the PLIN2 gene significantly impacts hair follicle growth cycles by affecting dermal papilla cell proliferation, offering insights into breeding strategies to enhance cashmere yield.
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    Research cited in this study 24

    1. Developmental Mapping of Hair Follicles in the Embryonic Stages of Cashmere Goats Using Proteomic and Metabolomic Construction Animals · 2023
    2. Genome-Wide Detection of RNA Editing Events During the Hair Follicles Cycle of Tianzhu White Yak BMC genomics · 2022
    3. Effect of the FA2H Gene on Cashmere Fineness of Jiangnan Cashmere Goats Based on Transcriptome Sequencing BMC Genomics · 2022
    4. Integrated Analysis of lncRNAs and mRNAs by RNA-Seq in Secondary Hair Follicle Development and Cycling (Anagen, Catagen, and Telogen) of Jiangnan Cashmere Goat (Capra hircus) BMC Veterinary Research · 2022
    5. Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats Genomics · 2022
    6. Wool Fiber Curvature Is Correlated With Abundance of K38 and Specific Keratin-Associated Proteins Proteins · 2021
    7. Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth Frontiers in Cell and Developmental Biology · 2021
    8. De Novo Filament Formation by Human Hair Keratins K85 and K35 Follows a Filament Development Pattern Distinct from Cytokeratin Filament Networks FEBS open bio · 2021
    9. Screening the Key Genes of Hair Follicle Growth Cycle in Inner Mongolian Cashmere Goat Based on RNA Sequencing Archiv für Tierzucht · 2020
    10. Molecular Basis of Maintaining Circannual Rhythm in the Skin of Cashmere Goat bioRxiv (Cold Spring Harbor Laboratory) · 2020
    11. Structural Behavior of Keratin-Associated Protein 8.1 in Human Hair as Revealed by a Monoclonal Antibody Journal of Structural Biology · 2018
    12. High-Throughput Sequencing of Hair Follicle Development-Related MicroRNAs in Cashmere Goat at Various Fetal Periods Saudi Journal of Biological Sciences · 2017
    13. LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway Animal Biotechnology · 2017
    14. The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family PloS one · 2016
    15. Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus) Genetics and molecular research · 2015
    16. Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling PloS one · 2013
    17. The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia Current opinion in cell biology · 2012
    18. Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat Journal of integrative agriculture/Journal of Integrative Agriculture · 2012
    19. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    20. Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth Archives of dermatological research · 2008
    21. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    22. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor Alpha Is Checked by ER Beta Signaling Endocrinology · 2005
    23. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999
    24. Growth Factors in Hair Organ Development and the Hair Growth Cycle Dermatologic Clinics · 1996

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