Comparative Effects of Finasteride and Minoxidil on Male Reproductive Organs: A Systematic Review of In Vitro and In Vivo Evidence

    October 2023 in “ Toxicology and Applied Pharmacology ”
    Francielle de Fátima Viana Santana, Amanda Alves Lozi, Reggiani Vilela Gonçalves … Sérgio Luís Pinto da Matta
    Studysummary This study found that finasteride and minoxidil act as hormone disruptors in mice, with finasteride having a more significant association with reproductive injuries, such as damage to the epididymis and reduced semen volume.
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    Research cited in this study 34

    1. Resveratrol Ameliorates the Seminiferous Tubules Damages Induced by Finasteride in Adult Male Rats Microscopy and Microanalysis · 2020
    2. Origanum Vulgare L. Leaves Extract Alleviates Testis And Sperm Damages Induced By Finasteride: Biochemical, Immunohistological And Apoptosis Genes Based Evidences Andrologia · 2020
    3. The physiology of male reproduction: Impact of drugs and their abuse on male fertility Andrologia · 2020
    4. Low-Dose Oral Minoxidil as Treatment for Non-Scarring Alopecia: A Systematic Review International Journal of Dermatology · 2020
    5. Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia Anais Brasileiros De Dermatologia · 2020
    6. Effects of AiQingHua Oil on Microcirculation Disturbance and Alopecia in Mice Models Journal of King Saud University. Science/Maǧallaẗ ǧāmiʹaẗ al-malik Saʹūd. al-ʹUlūm · 2020
    7. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    8. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    9. Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway Drug Design Development and Therapy · 2017
    10. Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases Oncotarget · 2016
    11. Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male Urologic Clinics of North America · 2016
    12. Morphometric-Stereological and Functional Epididymal Alterations and a Decrease in Fertility in Rats Treated with Finasteride and After a 30-Day Post-Treatment Recovery Period Fertility and Sterility · 2012
    13. Effects of Oral Finasteride on Erectile Function in a Rat Model The Journal of Sexual Medicine · 2012
    14. DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions Folia Histochemica et Cytobiologica · 2011
    15. Finasteride Expert Opinion on Drug Metabolism & Toxicology · 2010
    16. The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency Cellular & Molecular Biology Letters · 2009
    17. Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats Andrologia · 2008
    18. Androgens and Hair Growth Dermatologic Therapy · 2008
    19. The Effect of Finasteride on Spermatogenesis of Mesocricetus Auratus Acta Cirurgica Brasileira · 2008
    20. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    21. Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension Journal of Clinical Hypertension · 2004
    22. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    23. Effects of the Chronic Use of Finasteride on Testicular Weight and Spermatogenesis in Wistar Rats BJUI · 2002
    24. Finasteride, a Type 2 5α-Reductase Inhibitor, in the Treatment of Men with Androgenetic Alopecia Expert Opinion on Investigational Drugs · 1999
    25. Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp Journal of Dermatological Science · 1999
    26. Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment Neurobiology of Aging · 1995
    27. Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism Fundamental and applied toxicology · 1994
    28. Finasteride Blocks Progesterone Synthesis in MA-10 Leydig Tumor Cells Endocrinology · 1993
    29. Finasteride Drugs · 1993
    30. Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation Reproductive Toxicology · 1991
    31. Reversible Decreases of Fertility in Male Sprague-Dawley Rats Treated Orally with Finasteride, a 5α-Reductase Inhibitor Reproductive Toxicology · 1991
    32. Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster Archives of Dermatology · 1987
    33. Lack of a Gonadal or Adrenal Androgenic Mechanism for the Hypertrichosis Produced by Diazoxide, Phenytoin, and Minoxidil Biochemical Pharmacology · 1982
    34. Minoxidil Annals of Internal Medicine · 1981

    Related research 9

    1. Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients After Finasteride Treatment for a Year Journal of The American Academy of Dermatology · 2021
    2. Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients After Finasteride Treatment for a Year Zenodo (CERN European Organization for Nuclear Research) · 2020
    3. Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients After Finasteride Treatment for a Year Zenodo (CERN European Organization for Nuclear Research) · 2020
    4. Guidelines on the Use of Finasteride in Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2016
    5. Finasteride in the Treatment of Female Androgenic Alopecia PharmaTutor · 2014
    6. Daily Finasteride Boosts Hair Growth in Men Dermatology Times E-News · 2012
    7. Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats Andrologia · 2008
    8. Dutasteride Improves Hair Growth in Patients with Male Pattern Baldness More Effectively Than Finasteride Inpharma Weekly · 2007
    9. Reproducibility of Global Photographic Assessments of Patients With Male Pattern Baldness in a Clinical Trial With Finasteride Journal of Investigative Dermatology · 1995