Origanum Vulgare L. Leaves Extract Alleviates Testis And Sperm Damages Induced By Finasteride: Biochemical, Immunohistological And Apoptosis Genes Based Evidences

    September 2020 in “ Andrologia ”
    Xiaoning Chen, Hui Feng Ma, Attalla F. El-kott, Eman M Abd-Ella
    Studysummary This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.
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    Research cited in this study 10

    1. Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway Drug Design Development and Therapy · 2017
    2. Clinical Biochemistry of Dihydrotestosterone Annals of Clinical Biochemistry · 2013
    3. Finasteride 5 mg/Day Treatment of Patterned Hair Loss in Normo-Androgenetic Postmenopausal Women International Journal of Trichology · 2013
    4. Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage Fertility and Sterility · 2011
    5. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    6. Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
    7. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    8. 5-Alpha-Reductase 2 Inhibition Impairs Brain Defeminization of Male Rats: Reproductive Aspects Pharmacology Biochemistry and Behavior · 2005
    9. Effects of the Chronic Use of Finasteride on Testicular Weight and Spermatogenesis in Wistar Rats BJUI · 2002
    10. Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism Toxicological Sciences · 1994

    Related research 1

    1. Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility Biology of Reproduction · 2004