Evaluating the efficacy and safety of combined microneedling therapy versus topical Minoxidil in androgenetic alopecia: a systematic review and meta-analysis

    Khalid Ahmed, Yasmeena Abdelall Kozaa, Mohammad T. Abuawwad, Alaa I. Al-Najdawi, Yomna W. Mahmoud, Ahmed Ahmed, Mohammad J. J. Taha, Tamara Fadhli, Angeliki Giannopoulou
    TLDR Combined microneedling with minoxidil improves hair growth more than minoxidil alone but may cause mild side effects.
    This systematic review and meta-analysis, involving 631 patients across 12 randomized controlled trials, found that combined microneedling therapy (CMNT) with minoxidil significantly improves hair count and diameter in androgenetic alopecia (AGA) compared to minoxidil alone. While CMNT enhances hair growth by improving minoxidil absorption and stimulating hair follicle activity, it also results in more frequent, though generally mild, adverse events. The study suggests CMNT as a promising adjunctive treatment for AGA, with a safety profile comparable to minoxidil monotherapy. Further research is recommended to optimize treatment parameters and assess efficacy across diverse populations.
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