Epidermal Stem Cell Lineages: Roles in Skin Integrity, Stress Response, and Disease

    Lalhaba Oinam, Gopakumar Changarathil, Yen Xuan Ngo, Hiromi Yanagisawa, Aiko Sada
    TLDR Epidermal stem cells are crucial for skin health and problems with them can cause issues like poor wound healing, cancer, and aging.
    The review discussed the role of epidermal stem cells in maintaining tissue homeostasis and repairing injuries, highlighting recent advancements in understanding their properties and niches, particularly in the interfollicular epidermis (IFE). It emphasized the importance of new experimental techniques that have revealed different stem cell populations and their dynamics in mouse models. The review also covered the clonogenicity of primary human keratinocytes and the impact of stem cell heterogeneity on cancer and aging. The findings underscored the complex regulatory mechanisms involving intrinsic and extrinsic factors and interactions within the stem cell niche, suggesting that further research is needed to fully understand the biological significance of these highly compartmentalized stem cell populations.
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