Differentiation Genes Governed by DNA Methylation During Hair Follicle Morphogenesis in Cashmere Goats

    January 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Shanhe Wang, Fang Li, Jinwang Liu … Xin Wang

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that DNA methylation regulates hair follicle differentiation in cashmere goats by suppressing gene expression during induction and enhancing it during differentiation, with potential involvement of specific lncRNAs.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on biorxiv.org →
    Discuss this study in the Community →

    Research cited in this study 32

    1. Restoration of Hair-Inductive Activity of Cultured Human Follicular Keratinocytes by Co-Culturing with Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    2. Whole-Genome Bisulfite Sequencing of Goat Skins Identifies Signatures Associated with Hair Cycling BMC genomics · 2018
    3. The Inconsistent Regulation of HOXC13 on Different Keratins and the Regulation Mechanism on HOXC13 in Cashmere Goat (Capra Hircus) BMC Genomics · 2018
    4. The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells Cell Reports · 2018
    5. Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs Cell Cycle · 2018
    6. Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing International Journal of Biological Sciences · 2018
    7. Integrated Analysis of Coding Genes and Non-Coding RNAs During Hair Follicle Cycle of Cashmere Goat (Capra Hircus) BMC Genomics · 2017
    8. Hierarchical Patterning Modes Orchestrate Hair Follicle Morphogenesis PLoS Biology · 2017
    9. Functional Hair Follicle Regeneration Springer eBooks · 2017
    10. Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells Methods in molecular biology · 2017
    11. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    12. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    13. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    14. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    15. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012
    16. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    17. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011
    18. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    19. Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling Development · 2008
    20. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    21. Analysis of Hair Follicles in Mutant Laboratory Mice ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2005
    22. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    23. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    24. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    25. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002
    26. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    27. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables Experimental dermatology · 2001
    28. Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers Development · 2000
    29. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    30. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    31. Regulation of a Hair Follicle Keratin Intermediate Filament Gene Promoter Journal of Cell Science · 1998
    32. Regulation of Keratin Gene Expression in Hair Follicle Differentiation Annals of the New York Academy of Sciences · 1991

    Related research 7

    1. Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats Genomics · 2022
    2. Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape BMC genomics · 2020
    3. Skin Transcriptome Reveals the Periodic Changes in Genes Underlying Hair Follicle Cycling in Cashmere Goats Research Square (Research Square) · 2019
    4. Integrative Analysis Reveals ncRNA-Mediated Molecular Regulatory Network Driving Secondary Hair Follicle Regression in Cashmere Goats BMC Genomics · 2018
    5. Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus) Genetics and molecular research · 2015
    6. Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling PloS one · 2013
    7. Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat Journal of integrative agriculture/Journal of Integrative Agriculture · 2012