Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells
September 2021
in “Current Issues in Molecular Biology”
TLDR Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.
The study found that Dexpanthenol, a precursor of vitamin B5, promotes cell growth in human hair follicle cells by preventing cell senescence (aging) and apoptosis (cell death). It reduced the expression of apoptosis markers caspase 3 and caspase 9, and senescence markers p21 and p16. It also increased the expression of anagen (growth phase) markers, alkaline phosphatase (ALP) and β-catenin, and decreased the expression of TGF-β1, a protein that stimulates hair follicles to enter the catagen (regression) phase. Furthermore, Dexpanthenol stimulated the expression of VEGF, a protein that promotes hair growth, and its receptor in human outer root sheath cells (hORSCs), suggesting that Dexpanthenol induces the proliferation of hORSCs through VEGF signaling.
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