TLDR Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.
The study investigated the role of exosomes derived from dermal papilla cells (DPC-Exos) in hair follicle stem cell (HFSC) proliferation. It was found that DPC-Exos increased cell viability and reduced apoptosis in HFSCs. RNA sequencing identified 3702 differentially expressed genes in DPC-Exos-treated HFSCs, including LEF1, a gene associated with hair follicle development. Overexpression of LEF1 increased the expression of hair follicle development-related genes and proteins, enhanced HFSC proliferation, and reduced HFSC apoptosis. Conversely, knockdown of LEF1 reversed these effects. The study concluded that DPC-Exos can regulate HFSC proliferation by stimulating LEF1, providing new insights into hair follicle growth and development regulatory mechanisms.View this study on mdpi.com →
Stem cells and their secretions could potentially treat stress-induced hair loss, but more human trials are needed.
Hair follicle regeneration possible, more research needed.
Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
Stem cell technologies and regenerative medicine, including platelet-rich plasma, show promise for hair restoration in treating hair loss, but more research is needed.