Dermal PapillaCell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1
February 2023
in “International Journal of Molecular Sciences”
TLDR
Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.
The study investigated the role of exosomes derived from dermal papilla cells (DPC-Exos) in hair follicle stem cell (HFSC) proliferation. It was found that DPC-Exos increased cell viability and reduced apoptosis in HFSCs. RNA sequencing identified 3702 differentially expressed genes in DPC-Exos-treated HFSCs, including LEF1, a gene associated with hair follicle development. Overexpression of LEF1 increased the expression of hair follicle development-related genes and proteins, enhanced HFSC proliferation, and reduced HFSC apoptosis. Conversely, knockdown of LEF1 reversed these effects. The study concluded that DPC-Exos can regulate HFSC proliferation by stimulating LEF1, providing new insights into hair follicle growth and development regulatory mechanisms.
View this study on mdpi.com →
Cited in this study
research Exosomes Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation through the Wnt3a/β-Catenin Signaling Pathway
research Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review
Stem cells and their secretions could potentially treat stress-induced hair loss, but more human trials are needed.

research Functional hair follicle regeneration: an updated review
Hair follicle regeneration possible, more research needed.

research Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling
Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheres
Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research Conventional and novel stem cell based therapies for androgenic alopecia
Stem cell technologies and regenerative medicine, including platelet-rich plasma, show promise for hair restoration in treating hair loss, but more research is needed.