Image

    Dendrobium Officinale Polysaccharide Improves Hair Regrowth in Androgenetic Alopecia Mice and Is Associated with Coordinated Changes in Local Steroid Metabolism, ESR1 Activation, and Keratin-Related Follicular Responses

    May 2026 in “ Frontiers in Pharmacology ”
    Yuchen Ba, Junen Wang, Lin Qi … Dan Peng
    Studysummary In this study, DOP treatment improved hair regrowth in androgenetic alopecia by altering local steroid metabolism and follicular morphology.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 28

    1. MitoQ Upregulates CYP19A1 to Protect Dermal Papilla Cells from DHT-Induced Mitochondrial Dysfunction and Apoptosis in Androgenetic Alopecia Biochemical Pharmacology · 2026
    2. Androgenetic Alopecia Nature Reviews Disease Primers · 2025
    3. The Skin Microenvironment: A Dynamic Regulator of Hair Follicle Development, Cycling, and Disease Biomolecules · 2025
    4. Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment Drug Design Development and Therapy · 2025
    5. Single-Cell Sequencing Combined With Spatial Transcriptomics Reveals the Characteristics of Follicle-Targeted Inflammation Patterns in Primary Cicatricial Alopecia Cell & Bioscience · 2025
    6. A Comparative Proteomic-Based Study Identifies Essential Factors Involved in Hair Follicle Growth in Inner Mongolia Cashmere Goats BMC Veterinary Research · 2025
    7. MitoQ Enhances CYP19A1 Expression to Stimulate WNT/β-Catenin Signaling Pathway for Promoting Hair Growth in Androgenetic Alopecia European Journal of Pharmacology · 2024
    8. Comparative Proteomic Analysis of Male and Female Androgenetic Alopecia: Elucidating Gender-Specific Molecular Patterns Archives of Dermatological Research · 2024
    9. Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field Stem Cell Research & Therapy · 2024
    10. Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives Computational and Structural Biotechnology Journal · 2024
    11. Stimulation of Hair Regrowth in an Animal Model of Androgenic Alopecia Using 2-Deoxy-D-Ribose Frontiers in pharmacology · 2024
    12. Dendrobium Officinale Polysaccharide Promotes Angiogenesis, Follicle Regeneration, and Hair Growth Through Activation of the WNT Signaling Pathway Regenerative Therapy · 2024
    13. Androgenetic Alopecia: A Review Nigerian Postgraduate Medical Journal · 2024
    14. The Hormonal Background of Hair Loss in Non-Scarring Alopecias Biomedicines · 2024
    15. MRNA Levels of Aromatase, 5α-Reductase Isozymes, and Prostate Cancer-Related Genes in Plucked Hair from Young Men with Androgenic Alopecia International Journal of Molecular Sciences · 2023
    16. Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Identify Gene-Regulatory Programs and Critical Cell Types for Hair and Skin Diseases Nature Genetics · 2023
    17. A KRT71 Loss-of-Function Variant Results in Inner Root Sheath Dysplasia and Recessive Congenital Hypotrichosis of Hereford Cattle Genes · 2021
    18. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    19. 5α-Reductase Isozymes and Aromatase mRNA Levels in Plucked Hair from Young Women with Female Pattern Hair Loss Archives of Dermatological Research · 2017
    20. A Missense Mutation Within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2012
    21. Identification of the Rat Rex Mutation as a 7-Bp Deletion at Splicing Acceptor Site of the Krt71 Gene Journal of Veterinary Medical Science · 2010
    22. Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss British Journal of Dermatology · 2009
    23. Mutations in the Helix Termination Motif of Mouse Type I IRS Keratin Genes Impair the Assembly of Keratin Intermediate Filament Genomics · 2007
    24. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    25. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2006
    26. Estrogens And The Hair Follicle Journal der Deutschen Dermatologischen Gesellschaft · 2004
    27. A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles Journal of Investigative Dermatology · 2001
    28. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996