A Comparative Proteomic-Based Study Identifies Essential Factors Involved in Hair Follicle Growth in Inner Mongolia Cashmere Goats

February 2025 in “ BMC Veterinary Research ”

Rile Nai, Chongyan Zhang, Yuchun Xie, Man Duhu, Haijun Li, Lina Ma, Lu Mi, Meng Zhao, Qiaozhen Mu, Lixia Gao, Zhihong Liu, Jinquan Li

keratin proteins KRT25 KRT71 KRT82 secondary hair follicle growth TGF-beta signaling VEGF signaling Wnt signaling anagen stage telogen stage keratin transforming growth factor beta vascular endothelial growth factor wingless-related integration site

TLDR Keratin proteins are crucial for hair growth in cashmere goats.

This study on Inner Mongolia cashmere goats used SWATH mass spectrometry to analyze skin samples during the anagen and telogen stages of hair growth, identifying 2,414 proteins with 631 showing differential regulation. Key findings include the significant role of keratin proteins, particularly KRT25, KRT71, and KRT82, in secondary hair follicle growth. The study highlighted pathways related to metabolism, fatty acid degradation, and hair follicle growth, such as TGF-beta, VEGF, and Wnt signaling. The research involved three 2-year-old female goats and provides insights into the biological processes governing hair follicle development, with implications for improving cashmere production.

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Research cited in this study

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research The Intragenic mRNA-microRNA Regulatory Network During Telogen-Anagen Hair Follicle Transition in the Cashmere Goat

research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

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