Single-Cell Sequencing Combined With Spatial Transcriptomics Reveals the Characteristics of Follicle-Targeted Inflammation Patterns in Primary Cicatricial Alopecia

    July 2025 in “ Cell & Bioscience ”
    Qitao Chen, Yuqian Li, Qilin Zhu … Xufeng Du
    Studysummary Specific immune cells and pathways contribute to hair follicle inflammation and hair loss, suggesting potential treatments for lichen planopilaris.
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    Research cited in this study 18

    1. Epidermal Growth Factor Receptor/Mitogen-Activated Kinase Inhibitor Treatment Induces a Distinct Inflammatory Hair Follicle Response That Includes Collapse of Immune Privilege British Journal of Dermatology · 2024
    2. Interleukin-15 Is a Hair Follicle Immune Privilege Guardian Journal of Autoimmunity · 2024
    3. Tumor Necrosis Factor Inhibitors and Janus Kinase Inhibitors in the Treatment of Cicatricial Alopecia: A Systematic Review PloS one · 2024
    4. The Treatment of Primary Cicatricial Alopecia Is Challenging Journal of the American Academy of Dermatology · 2024
    5. Regulatory T Cells in Skin Mediate Immune Privilege of the Hair Follicle Stem Cell Niche Science Immunology · 2024
    6. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    7. Primary Cicatricial Alopecias Are Characterized by Dysregulation of Shared Gene Expression Pathways PNAS Nexus · 2022
    8. Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing British journal of dermatology/British journal of dermatology, Supplement · 2020
    9. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    10. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    11. Cicatricial Alopecia Research Foundation Meeting, May 2016: Progress Towards the Diagnosis, Treatment, and Cure of Primary Cicatricial Alopecias Experimental Dermatology · 2018
    12. Primary Cicatricial Alopecia: Treatment Approaches and Classification Journal of The American Academy of Dermatology · 2016
    13. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    14. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    15. Cicatricial (Scarring) Alopecias: Comprehensive Review and Management American Journal of Clinical Dermatology · 2012
    16. Eph/Ephrin Signaling in Epidermal Differentiation and Disease Seminars in Cell & Developmental Biology · 2011
    17. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    18. Dynamic Expression of the Zinc-Finger Transcription Factor Trps1 During Hair Follicle Morphogenesis and Cycling Gene Expression Patterns · 2007